|
老年人结构连接体对中风的脆弱性
The vulnerability of the structural connectome to stroke in older adults |
|
| |
| 课程网址: |
http://videolectures.net/snc2015_berlot_structural_connectome/
|
| 主讲教师: |
Rok Berlot
|
| 开课单位: |
卢布尔雅那大学
|
| 开课时间: |
2015-10-01
|
| 课程语种: |
英语
|
| 中文简介: |
策略性脑梗死描述了特定部位的病变如何对大脑功能产生不成比例的影响。战略位置可以反映运动或认知功能网络中的“瓶颈”。另一个假设是，战略效应是大脑网络结构的一个新特性。我们旨在研究模拟损伤对结构连接体整体性质的影响。模拟病变在两组位置进行：i）皮层下核团被认为是战略性脑梗死的部位；ii）高度连接的中枢，是大脑“丰富俱乐部”的一部分，是一组高度互联的中枢，介导大脑的远距离连接。39名53-93岁的健康志愿者接受了磁共振弥散加权成像。全脑束图用网络图表示。通过从图中移除一个节点及其连接来模拟病变。计算每个损伤引起的网络整体效率的比例变化。富俱乐部结节的病变比富俱乐部外的病变导致的整体效率下降更大。楔前病变的影响最大。在皮质下结节中，丘脑病变的易损性最高。年龄与丘脑损伤易感性呈正相关。50岁以上的健康人的结构连接体容易受到丰富的俱乐部节点的战略性损伤，尽管一些关键的枢纽位于很少受中风影响的部位。结构连接体对丘脑卒中的脆弱性随着年龄的增长而增加。这可能是年龄对中风预后影响的一个因素。
|
| 课程简介: |
Strategic infarction describes how lesions in particular locations have disproportionate effects on brain function. Strategic locations can reflect “bottlenecks” in functional networks for movement or cognition. Another hypothesis is that strategic effects are an emergent property of the brain’s network architecture. We aimed to examine the effect of simulated lesions on the global properties of the structural connectome. Simulated lesions were made in two sets of locations: i) subcortical nuclei recognised as sites of strategic infarction; ii) highly connected hubs that are part of the brain’s “rich club”, a group of highly interconnected hubs that mediate long-distance connectivity in the brain. 39 healthy volunteers aged 53-93 years underwent diffusion-weighted MRI. Whole-brain tractograms were represented as network graphs. Lesions were simulated by removing a node and its connections from the graph. The proportional change in network global efficiency due to each lesion was calculated. Lesions of rich-club nodes led to larger reductions in global efficiency than lesions outside the rich club. Lesions of the precunei produced the largest effect. Among subcortical nodes, vulnerability was highest for thalamic lesions. Age was positively correlated with vulnerability to lesions in the thalami. The structural connectome of healthy individuals aged over 50 is vulnerable to strategic lesions of rich-club nodes, though some of the key hubs are in sites rarely affected by stroke. The vulnerability of the structural connectome to thalamic stroke increases with age. This is likely to be a factor in the influence of age on stroke outcome.
|
| 关 键 词: |
病变; 战略性梗死; 大脑
|
| 课程来源: |
视频讲座网
|
| 数据采集: |
2020-12-21：yxd
|
| 最后编审: |
2020-12-25：chenxin
|
| 阅读次数: |
61
|
|
图 书 馆