图 书 馆
使用基于树的方法从表达数据中推断出监管网络Inferring regulatory networks from expression data using tree-based methods |
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| 课程网址: | http://videolectures.net/mlsb2010_huynh_thu_irn/ |
| 主讲教师: | Van Anh Huynh-Thu |
| 开课单位: | 列日大学 |
| 开课时间: | 2010-11-08 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | One of the pressing open problems of computational systems biology is the elucidation of the topology of genetic regulatory networks (GRNs) using high throughput genomic data, in particular microarray gene expression data. The Dialogue for Reverse Engineering Assessments and Methods (DREAM) challenge aims to evaluate the success of GRN inference algorithms on benchmarks of simulated data [11–13]. In this article, we present a new algorithm for the inference of GRNs that was best performer in the DREAM4 In Silico Multifactorial challenge3. In addition, we show that the algorithm compares favorably with existing algorithms to decipher the genetic regulatory network of Escherichia coli. It doesn’t make any assumption about the nature of gene regulation, can deal with combinatorial and non-linear interactions, produces directed GRNs, and is fast and scalable. An extended version of this works appears in [7]. |
| 关 键 词: | 计算系统生物学; 高通量基因组; 拓扑结构 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2021-12-22：liyy |
| 阅读次数: | 45 |