图 书 馆
微分方程定义的基因调控网络的极大似然估计Maximum Likelihood Estimation for a Gene Regulatory Network Defined by Differential Equations |
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| 课程网址: | http://videolectures.net/pesb07_lalam_mle/ |
| 主讲教师: | Nadia Lalam |
| 开课单位: | 查尔姆斯理工大学 |
| 开课时间: | 2007-04-04 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Gene regulation may be described by a set of deterministic differential equations describing the time rate evolution of the gene product concentrations, and containing parameters accounting for the regulatory relationships occurring in the gene network. We will present maximum likelihood based estimators of the parameters arising in this formalism and we will prove that they have desirable properties. Our results may be applied to a gene regulation model yielding the early Drosophila segments formation relying on a statistical modelling of gene expression data obtained by confocal laser scanning microscopy. The proposed statistical model accounts for the uncertainty in the measurement of gene expression and the uncertainty in the time at which the measurements are performed. |
| 关 键 词: | 基因调控; 微分方程; 最大似然估计 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-09-13：lxf |
| 阅读次数: | 63 |