图 书 馆
细胞代谢模型的守恒定律与可辨识性Conservation Laws and Identifiability of Models for Cellular Metabolism |
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| 课程网址: | http://videolectures.net/pesb07_wennberg_cla/ |
| 主讲教师: | Bernt Wennberg |
| 开课单位: | 查尔姆斯理工大学 |
| 开课时间: | 2007-04-04 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | New experimental techniques in the biosciences provide us with high-quality data allowing quantitative mathematical modeling. When fitting model parameters to experimental data, it is important to know whether all parameters can be uniquely estimated from available data. In this paper we discuss a class of models for metabolism, where the introduction of conserved moieties may cause an otherwise identifiable model to be unidentifiable. A general method for reparametrization to identifiable rate expressions is presented, and the general results are exemplified by three well-cited models for yeast metabolism. Joint work with Milena Anguelova, Gunnar Cedersuna, Carl Johan Franzen, Mikael Johansson |
| 关 键 词: | 定量数学建模; 代谢模型; 参数化 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-09-13：lxf |
| 阅读次数: | 58 |