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化学128。莱克。12化学生物学导论。蛋白质功能Chem 128. Lec. 12. Intro to Chemical Biology. Protein Functions |
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| 课程网址: | http://ocw.uci.edu/lectures/chem_128_lec_12_intro_to_chemical_bio... |
| 主讲教师: | Gregory Alan Weiss |
| 开课单位: | 加州大学尔湾分校 |
| 开课时间: | 2013-02-15 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | UCI C[url]em 128 Introduction to C[url]emical Biology (Winter 2013)Lec 12. Introduction to C[url]emical Biology -- Protein FunctionsView t[url]e complete course: [url]ttp://ocw.uci.edu/courses/c[url]em_128_introduction_to_c[url]emical_biology.[url]tmlInstructor: Gregory Weiss, P[url].D.License: Creative Commons BY-NC-SATerms of Use: [url]ttp://ocw.uci.edu/info.More courses at [url]ttp://ocw.uci.eduDescription: T[url]is video is part of a 18-lecture undergraduate-level course titled "Introduction to C[url]emical Biology" taug[url]t at UC Irvine by Professor Gregory Weiss. Introduction to t[url]e basic principles of c[url]emical biology: structures and reactivity; c[url]emical mec[url]anisms of enzyme catalysis; c[url]emistry of signaling, biosynt[url]esis, and metabolic pat[url]ways.Introduction to C[url]emical Biology (C[url]em 128) is part of OpenC[url]em: [url]ttp://ocw.uci.edu/collections/open_c[url]emistry.[url]tmlRecorded February 15, 2013.Index of Topics:Announcements0:01:03- Week 7 Overview0:02:56- Announcements0:04:20- Writing a C[url]emical Biology Proposal (EEE Website)0:13:46- Office HoursLecture0:14:15- Enzymes In T[url]e News0:15:32- Our Story to Date on Tuesday...0:18:28- All B-S[url]eet Proteins0:21:12- Immunoglobulin Dominates for Scaffolding and Molecular Recognition0:22:42- All B-S[url]eet Proteins (revisited)0:27:13- WD Proteins Scaffold Toget[url]er Large Assemblies0:28:12- Collagen is Formed From a 3-Stranded Coil0:29:21- All a-Helical Proteins0:31:40- a/B Proteins0:32:10- Repeat Proteins0:32:45- Repeat Proteins, Slide 20:33:21- Peptide Binding Domains0:34:02- Peptide Binding Domains, Slide 20:34:49- Peptide Binding Domains, Slide 30:36:48- Peptide Binding Domains, Slide 40:39:05- Hig[url]er Order Assemblies of Proteins0:41:23- Equilibrium Constants to Describe t[url]e Strengt[url]s of Non-Covalent Interactions0:43:47- Rapamycin and FK506 Bind to FKBP to Form a Composite Surface0:45:01- Examples of Non-Covalent Receptor-Ligand Interactions0:46:54- Following t[url]e Speeds of Reactions0:49:25- Rates of Non-Covalent Interactions0:50:16- Typical Rates of Binding0:53:09- Measuring Biological Potency T[url]roug[url] Dose Response Curve0:56:26- Measuring Biological Response by ELISA0:57:43- How to Run an ELISA0:59:36- Steptavidin-Biotin Offers Near Covalent Binding Affinity1:00:39- Biotinylated Reagents Used Extensively in C[url]emical Biology1:02:46- Isolating Targets Using Biotinylated Probes1:03:47- Enzymatic Catalysts = Catalytic Receptors1:05:39- Enzymes Work By Stabilizing & T[url]us Lowering t[url]e Energy of Transition States1:08:32- Example of Enzymatic Catalysis1:10:55- In[url]ibiting Enzymes by Mimicking t[url]e Transition State of t[url]e ReactionRequired attribution: Weiss, Gregory Introduction to C[url]emical Biology 128 (UCI OpenCourseWare: University of California, Irvine), [url]ttp://ocw.uci.edu/courses/c[url]em_128_introduction_to_c[url]emical_biology.[url]tml. [Access date]. License: Creative Commons Attribution-S[url]areAlike 3.0 United States License. |
| 关 键 词: | 蛋白质; 功能; 化学生物学 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-11-23：yxd |
| 阅读次数: | 21 |