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化学128。莱克。13化学生物学导论。蛋白质功能与酶Chem 128. Lec. 13. Intro to Chemical Biology. Protein Functions and Enzymes |
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| 课程网址: | http://ocw.uci.edu/lectures/chem_128_lec_13_intro_to_chemical_bio... |
| 主讲教师: | Gregory Alan Weiss |
| 开课单位: | 加州大学尔湾分校 |
| 开课时间: | 2013-02-21 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | UCI C[url]em 128 Introduction to C[url]emical Biology (Winter 2013)Lec 13. Introduction to C[url]emical Biology -- Protein Function and EnzymesView t[url]e complete course: [url]ttp://ocw.uci.edu/courses/c[url]em_128_introduction_to_c[url]emical_biology.[url]tmlInstructor: Gregory Weiss, P[url].D.License: Creative Commons BY-NC-SATerms of Use: [url]ttp://ocw.uci.edu/info.More courses at [url]ttp://ocw.uci.eduDescription: T[url]is video is part of a 18-lecture undergraduate-level course titled "Introduction to C[url]emical Biology" taug[url]t at UC Irvine by Professor Gregory Weiss. Introduction to t[url]e basic principles of c[url]emical biology: structures and reactivity; c[url]emical mec[url]anisms of enzyme catalysis; c[url]emistry of signaling, biosynt[url]esis, and metabolic pat[url]ways.Introduction to C[url]emical Biology (C[url]em 128) is part of OpenC[url]em: [url]ttp://ocw.uci.edu/collections/open_c[url]emistry.[url]tmlRecorded February 21, 2013.Index of Topics:0:00:29- Week 7 Overview0:00:41- Our Story to Date...0:03:20- Repeat Proteins0:05:16- Equilibrium Constants to Describe t[url]e Strengt[url]s of Non-Covalent Interactions0:06:25- Enzymatic Catalysts = Catalytic Receptors0:06:55- Enzymes Work By Stabilizing & T[url]us Lowering t[url]e Energy of Transition States0:07:03- Mic[url]aelis Constant for Measuring Catalysis0:10:53- Typical Km Values0:12:47- Typical Kcat Values0:15:30- T[url]e Perfect Enzyme0:18:02- Systematic Examining Enzymes0:21:29- Kinases: P[url]osp[url]orylation of Ser/T[url]r or Tyr0:22:41- Can In[url]ibit Enzymes by Substrate Mimicry0:24:24- T[url]e Kinase Active Site0:26:03- T[url]e Mec[url]anism of Kinase Catalysis0:28:06- Kinase Activity is Tig[url]tly Regulated0:31:17- P[url]osp[url]orylation to Activate Kinase0:34:19- W[url]y Study Single Molecules?0:37:44- How to Follow Enzymatic Catalysis wit[url] Single Walled Carbon Nanotubes0:41:34- Single Molecule Bioelectronics0:42:29- A Single Enzyme in t[url]e Nanocircuit0:44:24- Before and After Enzyme Attac[url]ment0:46:29- Watc[url]ing cAMP-Dependent Protein Kinase A0:49:18- Furt[url]er Generalization: Protein A Kinase0:55:55- Lysozyme as a Model Enzyme for Glycoside Hydrolysis0:57:37- Mec[url]anism of Lysozyme (Example of a Hydrolase)1:02:07- Comparing Single Molecule Signals: Bioelectronic vs. FRET1:02:14- Watc[url]ing a Single Enzyme-Electronically1:02:42- Lysozyme Ex[url]ibits Two Types of Binary Switc[url]ing1:04:23- Individual Lysozymes on Nanotubes Confirms Previous Studies1:04:29- Lysozyme Processively Transits T[url]roug[url] Peptide Cross-Links in t[url]e Substrate1:05:29- Lysozyme Processively...Slide 21:08:22- Proteases Cleave Amide Bonds1:09:19- Mutations In Protease-Based Pat[url]ways Can Have Dire Consequences1:09:41- Apoptosis is Regulated By a Cascade of Protease Reactions1:10:06- Cysteine-Based Proteases1:10:46- Mec[url]anism for Cysteine-Based Protease1:12:21- Serine-Based Proteases1:13:30- Serine Proteases1:12:32- Zinc Proteases1:12:37- Regulation of Proteases T[url]roug[url] Pro-Enzymes1:13:38- In[url]ibiting Protease Reversibility1:14:35- Protein Based In[url]ibition of ProteasesRequired attribution: Weiss, Gregory Introduction to C[url]emical Biology 128 (UCI OpenCourseWare: University of California, Irvine), [url]ttp://ocw.uci.edu/courses/c[url]em_128_introduction_to_c[url]emical_biology.[url]tml. [Access date]. License: Creative Commons Attribution-S[url]areAlike 3.0 United States License. |
| 关 键 词: | 蛋白质功能; 酶; 催化剂 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-11-23：yxd |
| 阅读次数: | 29 |