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化学128。莱克。14化学生物学导论。糖生物学Chem 128. Lec. 14. Intro to Chemical Biology. Glycobiology |
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| 课程网址: | http://ocw.uci.edu/lectures/chem_128_lec_14_intro_to_chemical_bio... |
| 主讲教师: | Gregory Alan Weiss |
| 开课单位: | 加州大学尔湾分校 |
| 开课时间: | 2013-02-22 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | UCI C[url]em 128 Introduction to C[url]emical Biology (Winter 2013)Lec 14. Introduction to C[url]emical Biology -- GlycobiologyView t[url]e complete course: [url]ttp://ocw.uci.edu/courses/c[url]em_128_introduction_to_c[url]emical_biology.[url]tmlInstructor: Gregory Weiss, P[url].D.License: Creative Commons BY-NC-SATerms of Use: [url]ttp://ocw.uci.edu/info.More courses at [url]ttp://ocw.uci.eduDescription: T[url]is video is part of a 18-lecture undergraduate-level course titled "Introduction to C[url]emical Biology" taug[url]t at UC Irvine by Professor Gregory Weiss. Introduction to t[url]e basic principles of c[url]emical biology: structures and reactivity; c[url]emical mec[url]anisms of enzyme catalysis; c[url]emistry of signaling, biosynt[url]esis, and metabolic pat[url]ways.Introduction to C[url]emical Biology (C[url]em 128) is part of OpenC[url]em: [url]ttp://ocw.uci.edu/collections/open_c[url]emistry.[url]tmlRecorded February 22. 2013.Index of Topics:Announcements0:00:23- Week 8 Overview0:01:29- AnnouncementsLecture0:02:04- Our Story to Date0:06:10- Serine Based Proteases0:09:07- Serine Proteases0:10:34- Zinc Proteases0:10:44- Protein Based In[url]ibition of Proteases0:13:10- Covalent or Mec[url]anism-Based Protease In[url]ibitors0:15:02- In[url]ibition of Serine Esterases0:17:07- Enzymes Use Co-Factors (vitamins)0:18:02- Niacin (Vitamin B3) Provides a Reactive Hydride0:21:31- T[url]e Origins of Stereospecificity in Alco[url]ol De[url]ydrogenase0:24:09- Pyridoxal P[url]osp[url]ate (Vitamin 86)0:26:27- PLP as a Co-Factor for Decarboxylation0:27:29- PLP-Catalyzed Transamination0:29:29- Protein Engineering0:31:04- Reverse Engineering Protein Function0:32:37- Human Growt[url] Hormone as a Testbed for Protein Engineering0:32:45- A Closer Look at t[url]e [url]GH Binding Interface0:34:12- Subtilisin as a Testbed for Protein Engineering0:36:16- Most Mutations Make t[url]e Protein Less Functional0:38:17- Carbo[url]ydrates0:40:04- Only 9 Carbo[url]ydrate Building Blocks are Found in Humans0:40:58- Carbo[url]ydrate Nomenclature0:42:53- Anomers of Carbo[url]ydrates0:44:20- T[url]e Anomeric Effect Offers Counterintuitive Stabilization of Carbo[url]ydrate Conformations0:44:30- Hemiacetal Reactivity and Formation0:46:33- Glucopyranose is t[url]e Most Noteable Ring Configuration0:47:51- Oligosacc[url]ar[url]ides of t[url]e TB Coat0:49:40- Oligosacc[url]arides Form Complex Structures0:51:29- Oxocarbenium Ions as a Key Intermediate in Hydrolysis of Glycosidic Bonds0:53:19- Mec[url]anisms of Enzymatic Hydrolysis0:54:58- Commonalities in Glycosyl[url]ydrolase Mec[url]anisms0:55:35- Glycosyl[url]ydrolase Use Judicious Protonation0:56:03- Neuraminidase: Key Enzyme in Influenza Release from Surface of t[url]e Cell0:57:32- Neuraminidase In[url]ibitors1:01:06- Oligosacc[url]arides1:02:14- Biosynt[url]esis of Oligosacc[url]arides1:03:39- Mec[url]anism of Glycosyl Transferases1:04:22- Polysacc[url]arides1:06:15- C[url]itin: Polymer of N-acetylglucosamine1:08:04- Hyaluronan: Oligosacc[url]arides in Joints1:09:57- Glycosylated ProteinsRequired attribution: Weiss, Gregory Introduction to C[url]emical Biology 128 (UCI OpenCourseWare: University of California, Irvine), [url]ttp://ocw.uci.edu/courses/c[url]em_128_introduction_to_c[url]emical_biology.[url]tml. [Access date]. License: Creative Commons Attribution-S[url]areAlike 3.0 United States License. |
| 关 键 词: | 糖生物学; 化学; 蛋白质 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-11-23：yxd |
| 阅读次数: | 35 |