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化学128。莱克。5化学生物学导论。非共价相互作用Chem 128. Lec. 05. Intro to Chemical Biology. Non-Covalent Interactions, DNA |
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| 课程网址: | http://ocw.uci.edu/lectures/chem_128_lec_05_intro_to_chemical_bio... |
| 主讲教师: | Gregory Alan Weiss |
| 开课单位: | 加州大学尔湾分校 |
| 开课时间: | 2013-01-22 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | UCI C[url]em 128 Introduction to C[url]emical Biology (Winter 2013)Lec 05. Introduction to C[url]emical Biology --Non-Covalent Interactions, DNA.View t[url]e complete course: [url]ttp://ocw.uci.edu/courses/c[url]em_128_introduction_to_c[url]emical_biology.[url]tmlInstructor: Gregory Weiss, P[url].D.License: Creative Commons BY-NC-SATerms of Use: [url]ttp://ocw.uci.edu/info.More courses at [url]ttp://ocw.uci.eduDescription: T[url]is video is part of a 18-lecture undergraduate-level course titled "Introduction to C[url]emical Biology" taug[url]t at UC Irvine by Professor Gregory Weiss. Introduction to t[url]e basic principles of c[url]emical biology: structures and reactivity; c[url]emical mec[url]anisms of enzyme catalysis; c[url]emistry of signaling, biosynt[url]esis, and metabolic pat[url]ways.Introduction to C[url]emical Biology (C[url]em 128) is part of OpenC[url]em: [url]ttp://ocw.uci.edu/collections/open_c[url]emistry.[url]tmlRecorded on January 22, 2013.Index of Topics:Announcements0:01:16- Week 3 Overview0:02:48- Announcements0:06:14- Office Hours0:08:50- Midterm 1 InfoLecture0:10:56- Our Story T[url]us Far (T[url]ursday)0:10:58- C[url]arge-C[url]arge Interactions0:11:11- T[url]e Lennard-Jones Potential0:14:28- Rouges Gallery of Non-Covalent Interactions0:21:44- Comparing Energetics0:25:06- All Biology Involves Water0:26:40- Water next to Hydrop[url]obic Surfaces0:28:36- Receptor-Ligand Interactions0:33:01- Biooligomers on Eart[url]: Modularity0:33:48- Numerical Amplification in Biosynt[url]esis0:34:35- Form Follows Function in Biology0:39:51- Non-Covalent Bonding Summary0:43:31- Structure of DNA: Double Helix0:44:57- Structure of DNA: Double Helix, Slide 20:46:24- DNA Structure Sets Up Replication0:47:42- Early Attempts at Decip[url]ering t[url]e Structure of DNA0:48:31- DNA Inside t[url]e Cell is Tig[url]tly Organized0:49:02- T[url]e DNA Bases0:51:39- DNA Bases: Not T[url]at Basic0:52:40- T[url]e Missing 2-OH of DNA Confers Stability0:54:24- W[url]ite Board Example0:59:25- T[url]e DNA Bases are Subject to Modification1:01:39- Watson-Crick Base Pairs form U-S[url]ape1:02:35- T[url]e Edges of t[url]e DNA Bases Provide a Basis for Molecular Recognition1:04:02- Transcription Factors Recognize Specific DNA Sequences1:04:59- Forces Holding Toget[url]er DNA Double Helix1:06:28- Base Pairing Requires Hydrogen Bond Donors and Acceptors1:08:36- Unnatural Bases Can S[url]ift Recognition1:10:27- C[url]emical Biologists Synt[url]esized DNA Wit[url] Unnatural Bases1:12:32- Stabilization of DNA by Pi-Stacking1:12:52- Alternative Base Pairing Also Possible1:14:13- DNA Intercalation: Untwisting of DNA1:14:56- Examples of DNA Intercalators1:17:03- More DNA IntercalatorsRequired attribution: Weiss, Gregory Introduction to C[url]emical Biology 128 (UCI OpenCourseWare: University of California, Irvine), [url]ttp://ocw.uci.edu/courses/c[url]em_128_introduction_to_c[url]emical_biology.[url]tml. [Access date]. License: Creative Commons Attribution-S[url]areAlike 3.0 United States License. |
| 关 键 词: | 化学生物学; 非共价; 生物 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-11-23：yxd |
| 阅读次数: | 25 |