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基于螺旋对序列分类的相互作用TM螺旋对三维建模Towards 3D modeling of Interacting TM Helix Pairs Based on Classification of Helix Pair Sequence |
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| 课程网址: | http://videolectures.net/prib2010_dyrka_t3mi/ |
| 主讲教师: | Witold Dyrka |
| 开课单位: | 华劳科技大学 |
| 开课时间: | 2010-10-14 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Spatial structures of transmembrane proteins are difficult to obtain either experimentally or by computational methods. Recognition of helix-helix contacts conformations, which provide structural skeleton of many transmembrane proteins, is essential in the modeling. Majority of helix-helix interactions in transmembrane proteins can be accurately clustered into a few classes on the basis of their 3D shape. We propose a Stochastic Context Free Grammars framework, combined with evolutionary algorithm, to represent sequence level features of these classes. The descriptors were tested using independent test sets and typically achieved the areas under ROC curves 0.60-0.70; some reached 0.77. |
| 关 键 词: | 蛋白空间结构; 进化算法; 螺旋构象 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-03-07：zyk |
| 最后编审: | 2021-03-10：zyk |
| 阅读次数: | 79 |