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在传染病病毒与宿主之间的相互作用
Virus-host Interactions in Infectious Diseases |
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| 课程网址: |
http://ocw.mit.edu/courses/biology/7-346-virus-host-interactions-...
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| 主讲教师: |
Sumana Sanyal; Joseph Ashour
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| 开课单位: |
麻省理工学院
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| 开课时间: |
2013-01-01
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| 课程语种: |
英语
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| 中文简介: |
病毒和人类之间的共同进化和适应通常被描述为零和生物军备竞赛。病毒进入宿主细胞，配备有一系列机制以逃避宿主防御反应并复制。病毒的快速突变允许各种感染方法的进化，这反过来推动了非特异性但高效的宿主机制的发展以限制感染。本课程将讨论各方开发的各种解决方案，以此作为生存手段。我们将使用从人类致病病原体中提取的实例，这些病原体严重影响全球健康负担，包括艾滋病毒，流感和登革热病毒。将讨论主要研究论文，以帮助学生学习提出科学问题，设计和进行实验来回答问题并批判性地解释数据。本课程是麻省理工学院生物系提供的许多高级本科研讨会之一。这些研讨会专为有兴趣使用初级研究文献的学生量身定制，以便在高度互动的环境中讨论和了解当前的生物学研究。高级本科生研讨会的许多讲师都是博士后科学家，他们对教学非常感兴趣。
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| 课程简介: |
Co-evolution and adaptation between viruses and humans are often portrayed as a zero-sum biological arms race. Viruses enter host cells equipped with an array of mechanisms to evade the host defense responses and replicate. The rapid rate of mutation of viruses permits evolution of various methodologies for infection, which in turn drive development of non-specific but highly effective host mechanisms to restrict infection. This class will discuss the varied solutions each side has developed as a means for survival. We will use examples drawn from human disease-causing pathogens that contribute seriously to the global health burden, including HIV, influenza and dengue virus. Primary research papers will be discussed to help students learn to pose scientific questions and design and conduct experiments to answer the questions and critically interpret data. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
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| 关 键 词: |
病毒; 宿主细胞; 病原体
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| 课程来源: |
麻省理工学院公开课
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| 最后编审: |
2020-10-21：yumf
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| 阅读次数: |
60
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