0


生化网络建模的计算环境

Computational environments for modeling biochemical networks
课程网址: http://videolectures.net/mlsb2010_kummer_cef/  
主讲教师: Ursula Kummer
开课单位: 海德堡大学
开课时间: 2010-11-08
课程语种: 英语
中文简介:
计算建模是系统生物学的重要组成部分。它依靠可访问的、用户友好的软件来建立模型、模型管理和模型分析。这里介绍了为满足这些需求而实施的两个系统。第一个是Copasi,自2004年以来就已经出现了,它是一个独立的软件套件,包含了计算建模中常用的许多算法和方法。除此之外,它还允许基于不同方法的实验数据集对模型进行参数估计。第二个软件是Sycamore,它是一个基于Web的应用程序,旨在允许数据库驱动的建模。因此,它直接与酶动力学数据库和根据蛋白质结构数据估算参数的工具相互作用。这两个系统都在不断地改进和添加功能。
课程简介: Computational modeling is an integral and crucial part of systems biology. It relies on accessible and user-friendly software to set up models, model management and model analysis. Here, two systems are presented that have been implemented for these needs. The first one, COPASI, has been around since 2004 and is a standalone software suite that encompasses many of the commonly used algorithms and approaches in computational modeling. Amongst others, it allows parameter estimation of model on the basis of experimental data sets with diverse methods. The second software is SYCAMORE which is a web based application designed to allow database driven modeling. Thus, it interacts directly with databases for enzymatic kinetics and with tools to estimate parameters based on protein structural data. Both systems are constantly refined and features added.
关 键 词: 计算建模; 系统生物学; 参数估计; 应用程序设计; 蛋白质结构数据
课程来源: 视频讲座网
最后编审: 2020-06-22:chenxin
阅读次数: 79