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通过检测运动意图和人工传入反馈调节皮层兴奋性

Modulation of Cortical Excitability by Detection of Motor Intention and Artificial Afferent Feedback
课程网址: http://videolectures.net/bbci2012_farina_cortical_excitability/  
主讲教师: Dario Farina
开课单位: 伯恩斯坦计算神经科学中心
开课时间: 2012-12-03
课程语种: 英语
中文简介:
脑-机接口(BCI)在功能恢复、功能替代和通信等方面有着广泛的应用。BCI系统的另一个潜在应用是,它可以促进运动和/或感觉功能(神经调节)恢复过程中的塑性变化,这方面的研究较少。在这个演讲中,我将集中讨论已经开发出来的方法,这些方法通过将运动指令与精确的时间延迟传递的人工传入波(例如电刺激)联系起来来改变人类的皮质兴奋性。在这些系统中,与运动想象相关的皮层激活(运动诱发皮层电位,MRCP)的在线检测相当于触发外部设备的异步BCI系统。研究表明,使用这些系统,连接相关大脑区域和目标肌肉的神经投射的兴奋性只有在传入流到达最高皮层激活阶段(从MRCPs测量)时才会增加。全异步BCI系统具有电刺激的触发机制,最近也在脑卒中患者中进行了测试,结果表明,它也促进了该患者群体的可塑性皮质改变,但试验数量有限。此外,在中风患者中,这种持续数天的干预也被证明可以改善功能恢复。
课程简介: Brain-computer interfaces (BCI) have applications in function restoration, function replacement, and communication. A further potential application of BCI systems, which has been less extensively investigated, is their use for promoting plastic changes during the recovery of motor and/or sensory functions (neuromodulation). In this talk, I will focus on methods that have been developed to change the cortical excitability in humans by associating motor commands and artificial afferent volley (e.g., electrical stimulation) delivered with precise temporal delay. In such systems, the online detection of cortical activation associated to movement imagination (motor evoked cortical potential, MRCP) is equivalent to an asynchronous BCI system that triggers an external device. It has been shown that, using these systems, the excitability of the neural projections connecting the relevant brain areas to the target muscle is increased only when the afferent inflow arrives during the highest cortical activation phase (measured from MRCPs). The full asynchronous BCI system with triggering of electrical stimulation has also been recently tested in stroke patients, showing that it promotes plastic cortical changes also in this patient population, with a limited number of trials. Moreover, in stroke patients, such intervention, repeated over several days, has also been shown to improve functional recovery.
关 键 词: 脑机接口; 功能替换; 通信方面
课程来源: 视频讲座网
最后编审: 2019-10-21:chenxin
阅读次数: 49