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Nanoparticles as drug delivery systems. The interaction with biomembrane models[纳米颗粒作为药物传递系统,与生物膜模型的相互作用
Nanoparticles as drug delivery systems. The interaction with biomembrane models[纳米颗粒作为药物传递系统,与生物膜模型的相互作用 |
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| 课程网址: |
http://videolectures.net/biophysics2018_garaiova_biomembrane_mode...
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| 主讲教师: |
Zuzana Garaiova
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| 开课单位: |
柯美纽斯大学
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| 开课时间: |
2018-07-09
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| 课程语种: |
英语
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| 中文简介: |
纳米颗粒（NPs）有助于保护包括新型治疗性生物分子（如核酸、蛋白质）在内的药物免受酶降解以及与生物成分的不良相互作用的影响，并有效地将其运输到治疗作用部位。为了这些目的，已经合成了不同种类的纳米颗粒（1）。我们将重点关注树状大分子等聚合物纳米颗粒，以及它们作为载体将HIV合成肽输送到树状细胞作为抗原呈递细胞的潜力，从而作为可能的HIV疫苗接种平台。由于细胞膜是运送货物进入细胞内空间的最重要障碍之一，因此分析生物膜相互作用至关重要。这可以通过使用各种仿生膜模型来实现，如朗缪尔单分子膜和脂质囊泡。我们已经证明，当模型膜和肽与NPs络合时，它们之间的相互作用比未络合（游离）肽更强。相互作用取决于脂质组成；聚乙二醇修饰的脂质使这种相互作用减弱（2）。
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| 课程简介: |
Nanoparticles (NPs) may help to protect drugs including new classes of therapeutic biomolecules (e.g. nucleic acids, proteins) from enzymatic degradation as well as from undesirable interactions with biological components, and efficiently transport them into the site of their therapeutic action. Different kind of nanoparticles has been synthesized for these purposes (1). We will focus on the polymer nanoparticles such as dendrimers and on their potential to be used as carriers for delivery of HIV synthetic peptides into dendritic cells serving as antigen-presenting cells, and thus, as a possible HIV vaccination platform. Since the cell membrane represents one of the most significant obstacles on the route of delivering cargo into the intracellular space, the analysis of biomembrane interactions is of utmost importance. This can be accomplished by using various biomimetic membrane models such as Langmuir monolayers and lipid vesicles. We have demonstrated that interaction between model membranes and peptides is stronger when being complexed with NPs than for uncomplexed (free) peptides. The interaction depended on the lipid composition; polyethyleneglycol modified lipids made this interaction weaker (2).
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| 关 键 词: |
纳米颗粒; 仿生膜模型; 新型治疗性生物分子
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| 课程来源: |
视频讲座网
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| 数据采集: |
2021-11-12：zkj
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| 最后编审: |
2021-11-12：zkj
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| 阅读次数: |
66
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