图 书 馆
第38讲-复习：可的松的合成Lecture 38 - Review: Synthesis of Cortisone |
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| 课程网址: | http://videolectures.net/yalespan125bs2011_mcbride_lec38/ |
| 主讲教师: | J. Michael McBride |
| 开课单位: | 耶鲁大学 |
| 开课时间: | 2014-08-19 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Discoverers of the structure and biological activity of steroid hormones won seven Nobel Prizes between 1927 and 1975. Studying the steps involved in Woodward's 1951 "total" synthesis of cortisone provides a review of the organic reactions covered this semester. Many steps involved novel insights, others were based on lore from previous work in the area. The overall yield of such sequential syntheses is typically much lower than that of convergent syntheses. Practical syntheses of cortisone were based on modification of related steroids readily available from nature. Milestones in total synthesis include both purely intellectual work with natural products and commercially important synthesis of designed pharmaceuticals. The course ends with thanks to those, young and old, who have taught us all. |
| 关 键 词: | 合成可的松; 类固醇激素; 药物合成 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-11-19：zkj |
| 最后编审: | 2021-11-19：zkj |
| 阅读次数: | 117 |