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Euro MOTOR：金属和溶剂暴露作为肌萎缩侧索硬化症危险因素的多中心人群病例对照研究

Euro-MOTOR: A multi-centre population-based case-control study of metals and solvents exposure as risk factors for amyotrophic lateral sclerosis
课程网址: http://videolectures.net/encals2017_rooney_euro_MOTOR/  
主讲教师: James P. K. Rooney
开课单位: 都柏林圣三一大学
开课时间: 2017-07-21
课程语种: 英语
中文简介:
导言：暴露于金属和溶剂被认为是包括肌萎缩侧索硬化症（ALS）在内的神经退行性疾病的一个风险因素，但由于难以评估历史暴露，研究变得复杂。方法：在爱尔兰、意大利和荷兰招募4年以上的ALS病例和配对对照。经过培训的调查人员对参与者进行了结构化访谈，以收集终生职业史的详细信息。将职业暴露矩阵（JEM）应用于职业数据，以表征农药暴露风险。使用年龄、性别、教育程度和队列调整的逻辑回归模型确定金属和溶剂暴露与ALS风险之间的关联。结果：纳入1557例患者和2922名对照者。我们发现ALS有任何暴露于空气中金属（OR=1.25 95%CI:1.05–1.49）和苯（OR=1.23 95%CI:1.06–1.43）的病史的优势比（OR）增加。这些发现对敏感性分析是可靠的，并且在校正体力活动、吸烟和饮酒后没有变化。只有在调整多个混杂因素后，才发现接触铬（OR=1.29 95%CI:1.02–1.64）和芳香族溶剂（OR 1.17 95%CI:1.00–1.36）的几率增加。讨论：我们的发现为欧洲人群中金属和溶剂暴露与ALS之间的关联提供了新的证据。进一步的工作正在进行中，以确定任何特定人群的差异和暴露-反应关系。
课程简介: Introduction: Exposure to metals and solvents have been proposed as a risk factor for neurodegenerative disorders including amyotrophic lateral sclerosis (ALS), however research has been complicated by difficulty in assessing historical exposures. Methods: Incident ALS cases and matched controls were recruited over 4 years in Ireland, Italy and the Netherlands. Trained investigators carried out structured interviews of participants to gather details of lifetime occupational history. JobExposure-Matrices (JEM) were applied to occupational data to characterize risk of exposure to pesticides. Logistic regression models adjusting for age, gender, education and cohort were used to determine the association between metal and solvent exposure and ALS risk. Results: 1,557 patients and 2,922 controls were included. We found increased odds ratios (ORs) for ALS with any history of exposure to any airborne metals (OR = 1.25 95% CI: 1.05 – 1.49) and benzene (OR = 1.23 95%CI: 1.06 – 1.43). These findings were robust to sensitivity analyses, and were unchanged after correction for physical activity, smoking and alcohol consumption. Increased odds for exposure to chromium (OR = 1.29 95% CI: 1.02 – 1.64) and aromatic solvents (OR 1.17 95%CI: 1.00 – 1.36) were found only after adjustment for multiple confounders. Discussion: Our findings provide new evidence for an association between metals and solvent exposure and ALS in European populations. Further work is ongoing to identify any population specific differences and exposure-response relationships.
关 键 词: 金属和溶剂; 肌萎缩侧索硬化症; 神经退行性疾病
课程来源: 视频讲座网
数据采集: 2021-12-25：zkj
最后编审: 2024-01-22：liyy
阅读次数: 42

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