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反馈机制和系统医学：药物发现中胆固醇稳态的建模Feedback mechanisms and systems medicine: Modeling cholesterol homeostasis for drug discovery |
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| 课程网址: | http://videolectures.net/mdo2014_acimovic_drug_discovery/ |
| 主讲教师: | Jure Ačimovič |
| 开课单位: | 卢布尔雅那大学 |
| 开课时间: | 2014-07-21 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Feedback mechanisms are the key features of cellular organisation; however, they can cause severe misinterpretation of the data. Cholesterol biosynthesis is a robust and highly regulated pathway; nevertheless, hypercholesteremia is a prevalent disease in the western world, which is seemingly contradicting. Statins are common drugs to treat hypercholesteremia in humans, taken by millions of people worldwide. Even if in principle safe, stat ins are known also for some severe adverse effects in particular patients. In the tutorial the participants will first design a very simple model of hypothetic metabolic pathway and observe its response to various simulated treatments. Next, a feedback will be introduced to the pathway and the simulated treatments will be repeated, to illustrate effects of the feedback loop. In the second part, the participants will get acquainted with the cholesterol biosynthesis model and will learn to simulate the effects of statins on cholesterol biosynthesis pathway as well as test some other treatment strategies. OpenModelica software will be used for the tutorial in combination with SysBio library for systems biology/medicine modelling. |
| 关 键 词: | 反馈机制; 高胆固醇血症; 系统生物学/医学建模 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-12-25：zkj |
| 最后编审: | 2021-12-27：liyy |
| 阅读次数: | 44 |