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杰基尔医生和海德先生:癌症中干细胞的双重性质

Doctor Jekyll and Mister Hyde: Dual nature of stem cells in cancer
课程网址: http://videolectures.net/NIBsimpozij2017_lah_turnsek_dual_nature/  
主讲教师: Tamara Lah Turnšek
开课单位: 国家生物研究所
开课时间: 2017-12-09
课程语种: 英语
中文简介:
Jekyll医生和Hyde先生:癌症中干细胞的双重性质希腊医生Hipokrates已经认识到癌症中存在干细胞,但基于科学的癌症干细胞概念最早是由病理学家鲁道夫·维肖在19世纪末提出的。生物技术的发展和当今对癌细胞功能分子网络的现代洞察,有助于肿瘤进展的分层概念的形成,这一概念由癌症干细胞驱动,此外还有助于更好地理解它们与肿瘤内相邻的非恶性细胞的相互作用。癌症干细胞正引发正常间充质干细胞的相反活动,旨在杀死杰基拉博士体内的海德亚先生,杰基拉博士正在发明一种对抗自己先天不足的药剂。本世纪初,恶性脑瘤和胶质母细胞瘤中也发现了癌症干细胞。由于它们不同寻常的特性和可塑性,在某些方面与经典细胞生物学的原理不符,它们经常被争论,甚至它们的存在也被否认。在这堂课中,我们将介绍我们最近关于胶质母细胞瘤干细胞的发现,以及它们与间充质干细胞的对话,这些细胞可以导致或多或少的侵袭性肿瘤。然而,如何影响善恶之间的斗争当然不仅仅是治疗癌症的问题!
课程简介: Doctor Jekyll and Mister Hyde: Dual nature of stem cells in cancer The existence of stem cells in cancer have already been perceived by Greek physician Hipokrates, but the scientifically based idea on cancer stem cells was first coined by pathologist Rudolf Virchow at the end of 19th century. The biotechnological development and today’s modern insights into molecular networks of cancer cells functioning, have contributed to the notion on hierarchical concept of tumour progression, driven by cancer stem cells and in addition to better understanding of their cross-talk with neighboring non-malignant cells within the tumour. Cancer stem cells are triggering the opposed activties by normal, mesenchymal stem cells, aiming at killing Mr Hydea)* in the body of Dr. Jekylla, who is inventing a potion against his own preveritve nature. Cancer stem cells have been recognized at the beginning of this century also in malignant brain tumour glioblastoma. Due to their unusual characteristics and plasticity, both in some aspects not in line with principles of classical cell biology, they are often debated and even their existence is denied. In this lecture, our recent findings on glioblastoma stem cells and their dialogue with mesenchymal stem cells that can lead to a more or a less aggressive tumor, will be presented. However, how to influence the fight between bad and good is of course not only the problem of curing cancer!
关 键 词: 干细胞的双重性质; 癌症干细胞; 胶质母细胞瘤
课程来源: 视频讲座网
数据采集: 2022-03-27:zkj
最后编审: 2022-03-27:zkj
阅读次数: 57