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微生物组与药物输送:健康与疾病中的跨物种交流

The Microbiome And Drug Delivery: Cross-Species Communication In Health And Disease
课程网址: https://ocw.mit.edu/courses/7-341-the-microbiome-and-drug-deliver...  
主讲教师: Dr. Ali Beyzavi; Dr. Miguel Jimenez
开课单位: 麻省理工学院
开课时间: 2018-01-01
课程语种: 英语
中文简介:
永久生活在我们肠道中的微生物比人体中的细胞还多。这种由细菌、真菌和病毒组成的丰富群落,称为微生物组,在人类健康和疾病中起着核心作用。最近的研究将这个乘客社区与营养、昼夜节律、传染病、炎症性疾病、癌症、糖尿病、关节炎甚至免疫系统和神经系统发育联系起来。我们如何分析这样一个复杂的系统?我们能利用微生物组来改善人类健康吗?能否利用与微生物的相互作用进行药物递送? 在本课程中,我们将学习批判性地评估主要科学文献,以找到这些问题的答案,并学会区分相关性和因果关系。我们将了解机制见解和新兴工具(如合成生物学和微流体)如何共同改变微生物组研究,并可能带来新型疗法和药物递送,以改善人类健康。 本课程是麻省理工学院生物系提供的众多高级本科研讨会之一。这些研讨会是为有兴趣使用主要研究文献在高度互动的环境中讨论和了解当前生物学研究的学生量身定制的。高级本科生研讨会的许多讲师都是对教学有浓厚兴趣的博士后科学家。
课程简介: There are more microbes permanently living in our gut than there are cells in the human body. This rich community of bacteria, fungi and viruses, called the microbiome, plays a central role in human health and disease. Recent research has linked this passenger community to nutrition, circadian rhythms, infectious disease, inflammatory disease, cancer, diabetes, arthritis and even immune system and nervous system development. How can we analyze such a complex system? Can we exploit the microbiome to improve human health? Can interactions with microbes be harnessed for drug delivery? In this course, we will learn to critically assess the primary scientific literature to find answers to these questions and learn to distinguish between correlation and causality. We will learn how mechanistic insights and emerging tools, such as synthetic biology and microfluidics, together are transforming microbiome research, and might lead to new types of therapeutics and drug delivery for improving human health. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
关 键 词: 人类健康; 微生物组; 新型疗法
课程来源: 麻省理工学院公开课
数据采集: 2023-12-07:chenjy
最后编审: 2023-12-07:chenjy
阅读次数: 5