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抗生素，毒素和蛋白质工程
Antibiotics, Toxins, and Protein Engineering |
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| 课程网址: |
http://ocw.mit.edu/courses/biology/7-344-antibiotics-toxins-and-p...
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| 主讲教师: |
Caroline Koehrer; Mandana Sassanfar
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| 开课单位: |
麻省理工学院
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| 开课时间: |
2007-01-01
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| 课程语种: |
英语
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| 中文简介: |
致命毒素蓖麻毒素（最着名的生物恐怖武器），白喉毒素（高度传染性细菌病的病原体）和广泛使用的抗生素四环素有一个共同点：它们专门针对细胞的转化装置并破坏蛋白质合成。在本课程中，我们将探讨毒素和抗生素的作用机制，它们在日常医学中的作用，以及耐药性的出现和传播。我们还将讨论新药物靶标的鉴定以及我们如何操纵蛋白质合成机制，为蛋白质工程提供有力工具，并为患有囊性纤维化和肌营养不良等破坏性疾病的患者提供潜在的新疗法。本课程是麻省理工学院生物系提供的许多高级本科研讨会之一。这些研讨会专为有兴趣使用初级研究文献的学生量身定制，以便在高度互动的环境中讨论和了解当前的生物学研究。高级本科生研讨会的许多讲师都是博士后科学家，他们对教学非常感兴趣。
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| 课程简介: |
The lethal poison Ricin (best known as a weapon of bioterrorism), Diphtheria toxin (the causative agent of a highly contagious bacterial disease), and the widely used antibiotic tetracycline have one thing in common: They specifically target the cell's translational apparatus and disrupt protein synthesis. In this course, we will explore the mechanisms of action of toxins and antibiotics, their roles in everyday medicine, and the emergence and spread of drug resistance. We will also discuss the identification of new drug targets and how we can manipulate the protein synthesis machinery to provide powerful tools for protein engineering and potential new treatments for patients with devastating diseases, such as cystic fibrosis and muscular dystrophy. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
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| 关 键 词: |
高度传染性; 四环素; 扰乱
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| 课程来源: |
麻省理工学院公开课
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| 最后编审: |
2020-10-21：yumf
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| 阅读次数: |
67
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