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阅读生活的蓝图：转录，干细胞和分化
7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation |
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| 课程网址: |
http://ocw.mit.edu/courses/biology/7-342-reading-the-blueprint-of...
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| 主讲教师: |
Dr. Matthew Guenther ; Dr. Roshan Kumar
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| 开课单位: |
麻省理工学院
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| 开课时间: |
信息不详。欢迎您在右侧留言补充。
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| 课程语种: |
英语
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| 中文简介: |
在本课程中, 我们将讨论转录调节剂在发展过程中如何禁止和推动分化。干细胞如何知道什么时候保持干细胞, 什么时候成为特定的细胞类型？在多能和最终分化的细胞中, 基因组的读取方式是否存在全球性差异？我们将探讨如何保持干细胞多能性, 细胞命运决定的主调节器如何执行发育计划, 以及染色质调节剂如何控制无分化或分化状态。此外, 我们将讨论转录调节剂的异常调节如何导致发育缺陷和癌症等疾病。本课程是麻省理工学院生物系提供的众多高级本科生研讨会之一。这些研讨会是为有兴趣利用初级研究文献在高度互动的环境中讨论和了解当前生物研究的学生量身定制的。高级本科生研讨会的许多教员都是对教学有浓厚兴趣的博士后科学家。
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| 课程简介: |
In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
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| 关 键 词: |
生命的蓝图; 转录; 干细胞; 分化; 人体组织; 组织再生; 人类疾病; RNA和蛋白质的表达模式; 转录调控; 特定的基因表达程序; 基因组
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| 课程来源: |
麻省理工大学公开课
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| 最后编审: |
2016-03-09：cmh
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| 阅读次数: |
25
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