生物动力系统中的一致性原理Consistency Principle in Biological Dynamical Systems |
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课程网址: | http://videolectures.net/eccs07_kaneko_cpb/ |
主讲教师: | Kunihiko Kaneko |
开课单位: | 东京大学 |
开课时间: | 2007-11-29 |
课程语种: | 英语 |
中文简介: | 我们提出了不同层次的一致性原则,以理解一个生物系统。讨论了三个主题。首先,由于分子复制和细胞复制的一致性,推导出了细胞化学丰度的普遍统计规律,实验也证实了这一点。它们包括基因表达的幂律分布,细胞上化学丰度的对数正态分布,以及将幂律嵌入网络连接中。其次,由于基因与表型的一致性,推导出了遗传变异引起的表型波动与发育噪声引起的等基因表型波动之间的一般关系。第三,从细胞繁殖的一致性和细胞系生长的一致性出发,探讨了具有自主调节的干细胞分化的混沌机制。 |
课程简介: | We propose consistency principle between different levels, to understand a biological system. Three topics are discussed. First, as a result of consistency between molecule replication and cell reproduction, universal statistical laws on chemical abundances over cells are derived as also confirmed experimentally. They include power-law distribution of gene expressions,log-normal distribution of chemical abundances over cells, and embedding of the power law into the network connectivity. Second, as a result of consistency between gene and phenotype,a general relationship between phenotype fluctuations by genetic variation and isogenic phenotypic fluctuation by developmental noise is derived. Third, we touch upon the chaos mechanism for stem cell differentiation with autonomous regulation, as a result of consistency of cell reproduction and growth of cell ensemble. |
关 键 词: | 生物动力系统; 分子复制; 细胞繁殖 |
课程来源: | 视频讲座网 |
最后编审: | 2021-01-31:nkq |
阅读次数: | 39 |