图 书 馆
利用主成分分析和聚类分析通过完整的线粒体序列揭示人类母系祖先Principal Component Analysis and Clustering Reveal Human Maternal Ancestry from Complete Mitochondrial Sequences |
|
| 课程网址: | http://videolectures.net/ephdcs08_bhanot_pcaacrhma/ |
| 主讲教师: | Gyan Bhanot |
| 开课单位: | 新泽西州立大学 |
| 开课时间: | 2008-10-15 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | We develop a simple, direct method to infer the phylogenetic tree for the maternal lineage of all humans using principal component analysis and consensus ensemble clustering. Unlike standard methods such as parsimony and maximum likelihood, our method is fast, gives a unique tree, makes no a-priori assumptions, uses all polymorphisms in the data and has high internal branch consensus. It confirms that modern humans came from Africa in at least two migrations and that the common maternal ancestor of humans or "mitochondrial Eve" lived in Africa ~200,000 years ago. It also suggests that the so called "R Clade", usually defined by a polymorphism at locus 12705 is too heterogeneous to have derived from a single common ancestor and places haplogroups B/R5/F in the Asian branch of the N Clade in agreement with their current location. |
| 关 键 词: | 线粒体; 祖先; 成分分析 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-12-05：lxf |
| 阅读次数: | 36 |