0


应变演化与疾病动力学的耦合

The coupling of strain evolution and disease dynamics
课程网址: http://videolectures.net/ephdcs08_wieland_tcoseadd/  
主讲教师: Stefan Wieland
开课单位: Gulbenkian科学研究所
开课时间: 2008-10-15
课程语种: 英语
中文简介:
甲型流感的特点是季节性爆发和逐渐遗传,但不连续的抗原进化(每4-7年发生一次抗原簇跳跃,由于人群缺乏免疫力而导致大规模季节性流行)。病毒突变与特定年龄组人类免疫反应之间的相互作用是在这里建模,试图解释观察到的现象,并根据上一年的动态预测下一季的流行菌株。
课程简介: Influenza A is characterized by seasonal outbreaks and a gradual genetic, yet discontinuous antigenic evolution (antigenic "cluster jumps" occuring every 4-7 years, with a large seasonal epidemic as a result of lacking immunity among the population).The interplay between viral mutations and an age-group-specific human immune response is modelled here, trying to account for the observed phenomena and to predict next season's epidemic strain from the dynamics of the previous year.
关 键 词: 生物学; 免疫; 疾病动力学
课程来源: 视频讲座网
最后编审: 2019-12-05:lxf
阅读次数: 41