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用于知识驱动的药物开发的临床研究的语义注释

Semantic Annotation of Clinical Studies for Knowledge-Driven Drug Development
课程网址: http://videolectures.net/estc08_popov_azsa/  
主讲教师: Borislav Popov; Vassil Momtchev
开课单位: 语义技术实验室
开课时间: 2010-12-24
课程语种: 英语
中文简介:
药物开发成本的不断上升使得制药公司必须从临床试验中获得的知识中快速学习。及时获得成功的研究设计和试验结果有助于在各个阶段提高决策的速度和质量。利用信息标准提取、整合和利用结构化和非结构化临床研究信息可能在这方面至关重要。本文将介绍我们在全球临床开发组织中实施的临床研究语义库。我们将讨论存储在大型临床文档库中的临床研究报告语义注释平台的设计。临床研究中提取的语义注释与来自全球试验执行数据库的结构化信息集成,并存储在组织语义库中。除了临床试验模型外,知识库还将现有的同义词库、词典和分类法纳入到一个句法连贯、语义健全的本体论中,并与之保持一致。
课程简介: The rising costs of drug development make it imperative for pharmaceutical companies to quickly learn from knowledge generated in clinical trials. Timely access to successful study designs and trial outcomes can facilitate speed and quality improvements in decision-making at various stages. Utilization of information standards for extraction, integration and exploitation of structured and unstructured clinical study information could prove to be critical in this context This talk will describe our implementation of a semantic repository of clinical studies in a global clinical development organization. We will discuss the design of a semantic annotation platform for clinical study reports stored in large clinical document repositories. The extracted semantic annotations over clinical studies are integrated with structured information from a global trial execution database and stored in an organizational semantic repository. Beside clinical trial models the repository also incorporated and aligned existing thesauri, dictionaries and taxonomies in a syntactically coherent and semantically sound ontology.
关 键 词: 语义网络; 药物开发; 语义标注; 临床研究
课程来源: 视频讲座网
最后编审: 2021-05-14:yumf
阅读次数: 31