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从实验和自然遗传扰动中重建网络Reconstructing networks from experimental and natural genetic perturbations |
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| 课程网址: | http://videolectures.net/licsb2010_markowetz_rne/ |
| 主讲教师: | Florian Markowetz |
| 开课单位: | 剑桥大学 |
| 开课时间: | 2010-05-03 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Functional genomics has demonstrated considerable success in inferring the inner working of a cell through analysis of its response to various perturbations. Perturbations can take the form of experimental interventions, like gene deletions or RNA interference, or natural perturbations, like SNPs or copy-number alterations. In my talk I will describe methods my lab has developed to reconstruct networks from the phenotypic effects of gene perturbations. In particular, I will (1) describe Nested Effects Models, a class of probabilistic graphical to reconstruct signaling pathways from downstream effects, and (2) introduce methods to correlate the impact of copy-number variation on gene expression with different sub-types of breast cancer. |
| 关 键 词: | 功能基因组学; 重建网络; 基因扰动; 概率图形 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-06-19：cxin |
| 阅读次数: | 25 |