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人类遗传学:我们的过去和我们的未来

Human Genetics: Our Past and Our Future
课程网址: http://videolectures.net/mitworld_altshuler_hg/  
主讲教师: David Altshuler
开课单位: 麻省理工学院
开课时间: 2011-10-12
课程语种: 英语
中文简介:
基因组学是要战胜我们最常见的疾病,还是建立一个基于卑鄙优生学的社会,或者两者兼而有之?DavidAltshuler在麻省理工学院博物馆的非正式谈话中概述了这些可能性。Altshuler是一个自我描述的乐观主义者,他在当前的基因研究中看到了希望,这项研究试图找出为什么有些人会患上像成人糖尿病或精神分裂症这样的疾病。如果我们能够确定细胞内发生紊乱的精确机制,对于遗传易患某种疾病的个体,那么设计药物就可能更准确。“我们正在寻找犯了罪的罪犯,其中罪犯是导致某人生病的DNA序列突变”…。科学家是侦探——CGI:犯罪基因调查员,Altshuler说。科学家们在人类基因组序列中有一个非常强大的工具,他们正在快速绘制出引起疾病的基因。但是,能够洞察疾病的工具也可能允许研究人员分离出其他人类特征的基因。Altshuler沉思道:“脱发、智力、犯罪、运动能力如何?社会是否应该规范遗传信息在生育选择中的使用?“如果保险公司能够接触到个人的遗传预测因素,并以此来确定风险和费率,会怎么样?Altshuler指出:“联邦法律没有阻止某人握手、刮去DNA、做基因测试、不雇佣你或拒绝给你保险的规定。”他说,最终,在限制基因信息的使用和允许其应用于治疗疾病之间取得平衡将是公众的责任。
课程简介: Will genomics vanquish our most common diseases, or create a society based on vile eugenics – or both? David Altshuler outlines these possibilities in his informal talk and conversation at the MIT Museum. Altshuler is a self-described optimist, and sees promise in current genetic research that attempts to pinpoint why some people develop diseases like adult-onset diabetes or schizophrenia. If we can identify the precise mechanisms inside cells that go haywire in individuals with an inherited predisposition to a certain disease, then it may be possible to design drugs much more accurately. “We’re searching for a culprit who committed a crime, where the culprit is a mutation in a DNA sequence that made somebody get sick …. And scientists are the detectives -- CGI: Crime Gene Investigators,” says Altshuler. Scientists have a very powerful tool in the human genome sequence, and they are quickly mapping out genes that cause diseases. But the very tools that permit insight into illness may also permit researchers to isolate genes for other human traits. And this has Altshuler musing: “How about hair loss, intelligence, criminality, athletic ability….Should society regulate the use of genetic information in reproductive choices?” What if insurance companies gain access to individuals’ genetic predictors, and use this to determine risk, and rates? “There’s no federal legislation to prevent someone from shaking your hand, scraping off DNA, doing a genetic test and not hiring you or refusing to give you insurance,” Altshuler points out. Ultimately, he says, it will be in the hands of the public to strike a balance between restricting the use of genetic information, and permitting its application to cure disease.
关 键 词: 生物学; 遗传学; 人类遗传学
课程来源: 视频讲座网
最后编审: 2020-05-22:吴雨秋(课程编辑志愿者)
阅读次数: 59