打开心灵之眼 - 学会看Opening the Mind’s Eye - Learning to See |
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课程网址: | http://videolectures.net/mitworld_sinha_ome/ |
主讲教师: | Pawan Sinha |
开课单位: | 麻省理工学院 |
开课时间: | 2010-08-12 |
课程语种: | 英语 |
中文简介: | 很少有研究能同时促进基础科学并为人们的生活带来好处,但Pawan Sinha的项目Prakash恰恰做到了这一点。Sinha是人类视觉处理的研究者,他对这些大脑机制的发展很感兴趣。在他的工作中,辛哈意识到理想的研究对象是失明后发展视力的个体。由于他无法在伦理上创造出这样一个实验群体,他不得不“依靠自然实验”——出生时失明的孩子,但他们恢复了视力。Sinha在印度发现了这些实验对象,印度是世界上失明儿童最多的国家,超过100万。他们是维生素A缺乏症、先天性白内障和缺乏或残暴的医疗护理的受害者。但是,Sinha的研究最为突出的是,许多失明儿童都可以接受治疗。他瞥见了一个人道主义和科学的机会,普拉卡什项目(梵语为光)诞生了。几年前,Sinha和他的团队开始在一些村庄对失明儿童进行筛查,以确定可治疗的失明病例,并对其进行治疗。最近,他得到了医院和学校对盲人的支持,接触到了更多的儿童。他开始建立一个测试人群。对这一独特群体的研究,对视觉的发展产生了许多独到的见解,动摇了一些主要的科学教条。辛哈发现,在多年没有视觉刺激的情况下,这些孩子的大脑可以处理新的信息,从而挑战大脑发育早期关键时期的概念。他发现,一旦病人仅仅通过触摸就知道了物体,一旦他们看到了,他们就可以通过观察来识别相同的物体。辛哈还深入研究了视觉整合的机制——我们的大脑如何理解包含不同颜色、光照和图案的视觉线索。他了解到,新发现的患者很难解析重叠的图像(如三角形、正方形、圆形),但将这些图像神奇地移动会激发识别。研究结果在各个年龄段都是一致的,并且表明视觉获取的早期阶段包括以碎片化的方式看待世界,牺牲识别能力,并且运动提示对于将图片有意义地组合在一起,为“视觉学习的一个关键引导功能”提供了至关重要的帮助。Prakesh儿童项目所经历的困难让人想起自闭症儿童的类似困难,对他们来说,运动处理似乎也有缺陷,Sinha现在正在寻找自闭症中可能的“因果链”,从而导致这种障碍的破坏性社会损害,这是一条可能有一天会产生的研究途径。新疗法 |
课程简介: | It’s rare to find research that simultaneously advances basic science and brings good into people’s lives, but Pawan Sinha’s Project Prakash does precisely that. An investigator of human visual processing, Sinha is interested in how these brain mechanisms develop. For his work, Sinha realized the ideal subjects would be individuals who developed sight after blindness. Since he could not ethically create such an experimental population, he had to “rely on natural experiments” -- children born blind, but who recovered their vision. Sinha found these subjects in his native India, which has the world’s highest number of blind children -- more than one million. They are victims of Vitamin A deficiency, congenital cataracts, and absent or atrocious medical care. But salient to Sinha’s research, many of these blind children could be treated. He glimpsed a humanitarian and scientific opportunity, and Project Prakash (Sanskrit for light) was born. Starting a few years ago, Sinha and his team began screening blind children in a few villages to identify cases of treatable blindness, and remedy their disorders. More recently, he’s gained support from hospitals and schools for the blind, reaching many more children. He began to establish a test population. Research on this unique group has yielded many original insights into the development of vision, and shaken some major scientific dogmas. Sinha found that after years without visual stimuli, the brains of these children could process new information flooding in -- challenging the notion of early critical periods in brain development. He discovered that patients who once learned about objects simply via touch could, once they gained sight, identify the same objects simply by looking at them. Sinha has also delved into the mechanisms of visual integration -- how our brains make sense of visual cues containing diverse colors, illumination, and patterns. He’s learned that newly sighted patients have difficulty parsing overlapping images (such as triangles, squares, circles), but moving these images around magically sparks recognition. Research results are consistent across all ages, and show that early stages of sight acquisition involve seeing the world in a fragmented way, compromising recognition, and that motion cues are critical for putting pictures together meaningfully, serving “a critical bootstrapping function for visual learning.” The kinds of integrative difficulties experienced by Project Prakesh children bring to mind similar difficulties in autistic children, for whom motion processing also seems to be deficient, and Sinha is now seeking a possible “causal chain in autism” that leads to the disorder’s devastating social impairments -- a research path that might someday yield new therapies. |
关 键 词: | 先天性白内障; 医疗保健; 视觉整合机制; 社交障碍 |
课程来源: | 视频讲座网 |
最后编审: | 2020-06-07:yumf |
阅读次数: | 55 |