图 书 馆
深度测序和系统生物学：对癌症患者的个性化治疗的方法步骤Deep sequencing and systems biology: steps on the way to an individualised treatment of cancer patients |
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| 课程网址: | http://videolectures.net/mlsb2010_lehrach_dss/ |
| 主讲教师: | Hans Lehrach |
| 开课单位: | 马克斯普朗克研究所 |
| 开课时间: | 2010-11-08 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Biological processes are driven by complex networks of interactions between molecular and cellular components. Predicting the outcome of potential disturbances is of prime importance to be able to prevent disease, as well as to identify possible therapies for diseases, which are already present. To predict the behaviour of such complex networks, we will have to develop general models of the processes involved, based on information on pathways derived from genetic and molecular approaches, to ‘individualise’ these by applying ‘genomics’ scale analysis techniques (e.g. genome and/or transcriptome analysis by next-gen sequencing techniques-genomics), and to explore the behaviour of these models computationally (systems biology). We are using a combination of high throughput sequencing of genome and transcriptome of both tumor and patient to establish predictive models (virtual patients), which ultimately will reflect the response of real patients to specific therapies in oncology and other areas of medicine. |
| 关 键 词: | 遗传学; 分子生物学; 系统生物学; 医学肿瘤学 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-06-01：wuyq |
| 阅读次数: | 51 |