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一种遗传重组的高分子模型

Towards a Polymer Model of Genetic Recombination
课程网址: http://videolectures.net/pim07_penfold_tpm/  
主讲教师: Christopher Penfold
开课单位: 华威大学
开课时间: 2007-11-06
课程语种: 英语
中文简介:
同源重组(HR)是指在细胞分裂过程中,例如减数分裂和有丝分裂,以及对环境诱导的遗传损伤的反应中,遗传物质的重组。HR优先出现在某些区域,并且受染色体包装引起的物理区域化的显著影响。虽然存在许多实验技术来识别这种效果,但它们通常是昂贵和耗时的。在这里,我们建议使用贝叶斯方法与机械先验进行重新组合,这样我们就可以推断出可能缺少实验数据的区域之间的重组频率和效率的后验分布。
课程简介: Homologous recombination (HR) refers to the shuffling of genetic material during cellular division e.g., meiosis and mitosis, and in response to environmentally-induced genetic damage. HR occurs preferentially over certain regions, and is notably influenced by physical compartmentalization due to chromosome packing. Although a number of experimental techniques exist for identifying such effect they are generally costly and time-consuming. Here we suggest a Bayesian approach to recom- bination with a mechanistic prior such that we may infer posterior distributions for recombination frequencies and efficiencies between regions where experimental data may be absent.
关 键 词: 技术; 纳米技术; 纳米电子学
课程来源: 视频讲座网
最后编审: 2020-06-02:毛岱琦(课程编辑志愿者)
阅读次数: 45