用熵是由进化突变事件所确定的信息理论来预测蛋白质家族结构域数据库的不断发展Predicting co-evolving pairs in Pfam using information theory where entropy is determined by phylogenetic mutation events |
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课程网址: | http://videolectures.net/pmsb06_willis_peppu/ |
主讲教师: | Scooter Willis |
开课单位: | 佛罗里达大学 |
开课时间: | 2007-02-25 |
课程语种: | 英语 |
中文简介: | 蛋白质序列共进化对的精确预测在三级蛋白质结构预测和蛋白质工程中具有重要作用。利用信息理论检测共进化对受到系统发育对熵测量的影响。基于系统发生树(RPE)中的突变事件,利用互信息(MI)方法检测蛋白质家族中的共进化对。 |
课程简介: | The accurate prediction of co-evolving pairs in protein sequences plays an important role in tertiary protein structure prediction and protein engineering. Using information theory to detect co-evolving pairs is impacted by the phylogenetic effect on entropy measurements. Mutual Information (MI) is used to detect co-evolving pairs in a protein family by re-sampling based on mutation events in the phylogenetic tree (RPE). |
关 键 词: | 蛋白质序列; 结构预测; 互信息 |
课程来源: | 视频讲座网 |
最后编审: | 2020-06-02:张荧(课程编辑志愿者) |
阅读次数: | 29 |