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探索利用同源三态熵向量的概念

Exploring Homology Using the Concept of Three-State Entropy Vector
课程网址: http://videolectures.net/prib2010_pinho_ehuc/  
主讲教师: Pinho Armando J
开课单位: 阿威罗电子与远程信息工程学院
开课时间: 2010-10-14
课程语种: 英语
中文简介:
通常在外显子中发现的三个碱基周期性被用于几个目的,例如预测潜在基因。在本文中,我们使用先前提出的编码DNA序列蛋白质编码区域的数据模型来构建能够支持有意义的树状图构建的签名。该模型依赖于三个碱基的周期性,并提供了与密码子三个碱基中每个碱基相关的熵的估计。我们观察到这三个熵值在不同物种之间也不同。此外,我们还提供了证据,证明了将一个三态熵向量与每个物种关联起来是可能的,并且证明了相似物种具有相似的三态熵向量。
课程简介: The three-base periodicity usually found in exons has been used for several purposes, as for example the prediction of potential genes. In this paper, we use a data model, previously proposed for encoding protein-coding regions of DNA sequences, to build signatures capable of supporting the construction of meaningful dendograms. The model relies on the three-base periodicity and provides an estimate of the entropy associated with each of the three bases of the codons. We observe that the three entropy values vary among themselves and also from species to species. Moreover, we provide evidence that this makes it possible to associate a three-state entropy vector with each species, and we show that similar species are characterized by similar three-state entropy vectors.
关 键 词: 潜在基因; 数据模型; 编码蛋白; 三态熵向量
课程来源: 视频讲座网
最后编审: 2020-06-03:毛岱琦(课程编辑志愿者)
阅读次数: 60