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RNA干扰:一个新的基因分析与治疗的工具7.344 RNA Interference: A New Tool for Genetic Analysis and Therapeutics |
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| 课程网址: | http://ocw.mit.edu/courses/biology/7-344-rna-interference-a-new-t... |
| 主讲教师: | Dr. Stephane Kissler; Dr. Andrea Ventura |
| 开课单位: | 麻省理工学院 |
| 开课时间: | 信息不详。欢迎您在右侧留言补充。 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. To understand and treat any disease with a genetic basis or predisposition, scientists and clinicians need effective ways of manipulating the levels of genes and gene products. Conventional methods for the genetic modification of many experimental organisms are technically demanding and time consuming. Just over 5 years ago, a new mechanism of gene-silencing, termed RNA interference (RNAi), was discovered. In addition to being a fascinating biological process, RNAi provides a revolutionary technology that has already changed the way biomedical research is done and that may even prove useful for genetic interventions in a clinical context. In this course, students learn how RNAi was discovered, how it works, and what its physiological relevance might be. How RNAi can be harnessed to modulate gene expression and perform genetic screens, both in cells and in various organisms is also covered. Finally, this course examines the first attempts to use RNAi for the treatment of models of human diseases in experimental animals. |
| 关 键 词: | RNA干扰; 基因分析; 基因工程; 基因表达; 遗传筛选; 核苷酸片段 |
| 课程来源: | 信息不详。欢迎您在右侧留言补充。 |
| 最后编审: | 2017-04-08：lkn |
| 阅读次数: | 27 |