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使用简单的生物体来模拟人类疾病

7.345 Using Simple Organisms to Model Human Diseases (MIT)
课程网址: http://ocw.mit.edu/courses/biology/7-345-using-simple-organisms-t...  
主讲教师: Dr. Katie Harris
开课单位: 麻省理工学院
开课时间: 信息不详。欢迎您在右侧留言补充。
课程语种: 英语
中文简介:
科学家如何发现人类疾病的基础生物学?面包酵母、线虫、果蝇、斑马鱼、小鼠和大鼠等简单生物使生物学家能够从分子到行为多层次地研究疾病。在本课程中,学生将通过批判性阅读和讨论初级研究文章来学习疾病建模的策略。我们将探讨目前神经退行性疾病的模型,如帕金森氏病,儿童遗传疾病,如脆性X综合征,以及耳聋和伤口愈合的模型。我们的目标是理解生物学家用来建立人类疾病适当模型的策略,并理解使用简单生物体来分析人类疾病的力量和局限性。这门课程是麻省理工学院生物学系提供的众多高级本科研讨会之一。这些研讨会是为有兴趣使用初级研究文献的学生量身定制的,旨在在高度互动的环境中讨论和学习当前的生物研究。许多高级本科生研讨会的导师都是对教学有浓厚兴趣的博士后科学家。
课程简介: How do scientists discover the basic biology underlying human diseases? Simple organisms such as baker’s yeast, nematodes, fruit flies, zebrafish, mice and rats have allowed biologists to investigate disease at multiple levels, from molecules to behavior. In this course students will learn strategies of disease modeling by critically reading and discussing primary research articles. We will explore current models of neurodegenerative diseases such as Parkinson’s disease, childhood genetic diseases such as Fragile X syndrome, as well as models of deafness and wound healing. Our goal will be to understand the strategies biologists use to build appropriate models of human disease and to appreciate both the power and limitations of using simple organisms to analyze human disease. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
关 键 词: 疾病建模; 神经变性疾病; 基础生物学
课程来源: 信息不详。欢迎您在右侧留言补充。
最后编审: 2017-04-08:lkn
阅读次数: 32