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生命，疾病和癌症医学中的血管生长
7.345 Vascular Development in Life, Disease and Cancer Medicine (MIT) |
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| 课程网址: |
http://ocw.mit.edu/courses/biology/7-345-vascular-development-in-...
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| 主讲教师: |
Dr. Alexandra Naba; Dr. Christopher Turner
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| 开课单位: |
麻省理工学院
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| 开课时间: |
信息不详。欢迎您在右侧留言补充。
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| 课程语种: |
英语
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| 中文简介: |
血管的生长，一个称为血管生成的过程，是哺乳动物发育中最早的事件之一，由生长因子和其他分子的敏感相互作用调节。在本课程中，我们将讨论血管发育的关键分子调节器，以及血管生物学家所使用的技术和实验系统。我们还将检验食品和药物管理局（FDA）批准的几种抗血管生成治疗的成功率，这些治疗抑制血管生成前血管内皮生长因子（VEGF），目前正用于治疗年龄相关的黄斑变性。最后，我们将探讨在癌症进展的过程中，如何将血液供应建立成肿瘤，从而导致癌细胞的生长和扩散到次要部位。我们将讨论靶向肿瘤血管以使癌细胞挨饿和防止癌症扩散的注意事项和潜在缺陷，这仍然是美国死亡的主要原因之一。本课程是麻省理工学院生物学系提供的许多高级本科研讨会之一。这些研讨会是为有兴趣使用初级研究文献的学生量身定制的，旨在在高度互动的环境中讨论和学习当前的生物研究。许多高级本科生研讨会的导师都是对教学有浓厚兴趣的博士后科学家。
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| 课程简介: |
The growth of blood vessels, a process known as angiogenesis, is one of the earliest events in mammalian development and is regulated by a sensitive interplay of growth factors and other molecules. In this course, we will discuss the key molecular regulators of blood vessel development as well as the techniques and experimental systems that have been utilized by vascular biologists. We will also examine the success of several anti-angiogenic treatments that have been approved by the Food and Drug Administration (FDA), that inhibit the pro-angiogenic vascular endothelial growth factor, VEGF, and that are now being used to treat age-related macular degeneration. Finally, we will explore how during the course of cancer progression, establishment of a blood supply into a tumor can lead to the growth and spread of cancer cells to secondary sites. We will discuss the caveats and potential pitfalls of targeting tumor blood vessels to starve cancer cells and prevent the spread of cancer, which remains one of the leading causes of death in the USA. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
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| 关 键 词: |
血管生成; 生长因子; 活体成像; 癌症进展; 癌症传播
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| 课程来源: |
信息不详。欢迎您在右侧留言补充。
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| 最后编审: |
2017-04-08：lkn
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| 阅读次数: |
55
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