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系统生物学

8.591J / 7.81J / 9.531J Systems Biology
课程网址: http://ocw.mit.edu/courses/physics/8-591j-systems-biology-fall-20...  
主讲教师: Prof. Alexander van Oudenaarden
开课单位: 麻省理工学院
开课时间: 2004-01-01
课程语种: 英语
中文简介:
本课程介绍了解决现代生物学中关键问题所需的数学建模技术。概述了分子生物学和遗传学、细胞生物学和发育生物学中的建模技术。还讨论了验证数学模型的关键实验,以及分子、细胞和发育系统生物学、细菌趋化性、遗传振荡器、控制理论和遗传网络以及梯度传感系统。其他具体主题包括:构建和建模遗传网络、作为遗传开关的lambda噬菌体、合成遗传开关、昼夜节律、反应扩散方程、局部激活和全局抑制模型、中心发现网络、一般模式形成模型、模拟细胞-细胞通信、群体感应,最后,果蝇发育模型。
课程简介: This course introduces the mathematical modeling techniques needed to address key questions in modern biology. An overview of modeling techniques in molecular biology and genetics, cell biology and developmental biology is covered. Key experiments that validate mathematical models are also discussed, as well as molecular, cellular, and developmental systems biology, bacterial chemotaxis, genetic oscillators, control theory and genetic networks, and gradient sensing systems. Additional specific topics include: constructing and modeling of genetic networks, lambda phage as a genetic switch, synthetic genetic switches, circadian rhythms, reaction diffusion equations, local activation and global inhibition models, center finding networks, general pattern formation models, modeling cell-cell communication, quorum sensing, and finally, models for Drosophila development.
关 键 词: 分子生物学; 细胞生物学; 遗传学; 发育生物学
课程来源: 麻省理工学院公开课
最后编审: 2024-01-26:chenjy
阅读次数: 42