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一个为锁定患者设置的基于实时功能磁共振成像的健壮拼写装置
A Robust Spelling Device for Locked-In Patients Based on Real-Time fMRI |
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| 课程网址: |
http://videolectures.net/bbci09_goebel_arsd/
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| 主讲教师: |
Rainer Goebel
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| 开课单位: |
马斯特里赫特大学
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| 开课时间: |
2009-08-10
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| 课程语种: |
英语
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| 中文简介: |
一些医疗条件（如脑损伤、中风、进行性神经疾病）可导致完全瘫痪，同时在很大程度上保留了感觉和认知功能以及相关的大脑激活。我们调查了健康受试者是否能够仅在自愿控制功能磁共振（粗体）信号的基础上进行书写。使用引导显示技术，我们证明受试者可以在不到半小时的时间内学习，从而在一次试验中可靠地产生字母表中的任何字母。为了达到这个效果，受试者使用三种心理策略来调节三个不同脑区的功能磁共振信号的时空特性。虽然传输的信息（来自感兴趣区域的粗体时间进程）最初是由人类评估者离线解码的，但我们最近实现了一种完全自动化的实时脑阅读技术。开发的范例和解码技术可以应用于锁定患者，让他们传达他们的愿望。在没有广泛的预培训的情况下，ND思维是可靠的。
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| 课程简介: |
Several medical conditions (e.g., brain injury, stroke, progressive neurological diseases) can lead to complete paralysis while largely preserving sensory and cognitive functions and associated brain activation. We investigated whether healthy subjects are able to "write" solely on the basis of voluntary control of the fMRI (BOLD) signal. Using a guided display technique, we show that subjects can learn in less than half an hour to produce reliably any letter of the alphabet in a single trial. To achieve this performance, subjects use three mental strategies to modulate spatio-temporal properties of the fMRI signal in three different brain areas. While the transmitted information (BOLD time courses from regions-of-interest) has been initially decoded offline by human raters, we have recently implemented a fully automatized real-time "brain reading" technique.The developed paradigm and decoding technique might be applied in locked-in patients to let them communicate their wishes and thoughts reliably without extensive pre-training.
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| 关 键 词: |
神经系统疾病; 磁共振成像; 开发范式; 解码技术
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| 课程来源: |
视频讲座网
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| 最后编审: |
2020-09-21：heyf
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| 阅读次数: |
39
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