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记录峰值…无创性吗?

Recording Spikes ... Noninvasively?
课程网址: http://videolectures.net/bbci2012_curio_recording_spikes/  
主讲教师: Gabriel Curio
开课单位: 柏林查尔特大学
开课时间: 2012-10-03
课程语种: 英语
中文简介:
峰值的可检测性定义了有创(显微镜)和无创(宏观)神经生理测量之间的显著对比。虽然无创记录主要是反映神经元输入的突触后电位的总和,但有创电极也可以方便地访问神经元计算峰值的输出。然而,在过去的几年里,这种微观/宏观的差距已经逐渐缩小,通过将特殊的生理学范式与神经技术的进步相结合。为了传达本研究议程关于高频尖峰相关脑电图(EEG/MEG)的要点,三方讲座将(i)讨论区分缓慢和快速神经元活动的近场和远场信号的基本神经物理学,(i i)详细阐述高频(~600赫兹)体感诱发反应,作为工作马(Workhorse)对ESTA的作用。在非专业实验室发表无创性尖峰相关记录的可行性,以及(iii)关于最近神经技术进展的报告,为脑电图活动的高分辨率头皮成像提供了一个独特的机会,甚至高于1 kHz,反映了人新皮层人群尖峰反应的无创相关性。
课程简介: The detectability of spikes defines a striking contrast between invasive (microscopic) and noninvasive (macroscopic) neurophysiological measurements. While noninvasive records are dominated by summed postsynaptic potentials reflecting neuronal input, invasive electrodes can provide easy access also to the very output of neuronal computation – spikes. This micro/macro gap, however, has been narrowed gradually over the last years by combining special physiological paradigms with neurotechnological advances. To convey the gist of this research agenda on high-frequency spike-related EEG/MEG the tripartite lecture will (i) address the basic neurophysics of near-field and far-field signals distinguishing slow from fast neuronal activities, (ii) elaborate on high-frequency (~600 Hz) somatosensory evoked responses serving as ‘workhorse’ to establish the feasibility of noninvasive spike-related recordings also in non-specialised labs, and (iii) report on recent neurotechnological progress providing a unique opportunity for high-resolution scalp mappings of EEG activities even above 1 kHz which reflect noninvasive correlates of human neocortical population spike responses.
关 键 词: 神经生理学; 高分辨率脑电图; 群峰电位反应报告
课程来源: 视频讲座网
最后编审: 2020-07-14:yumf
阅读次数: 52