0


7.342 癌症生物学:从基础研究到临床

7.342 Cancer Biology: From Basic Research to the Clinic
课程网址: http://ocw.mit.edu/courses/biology/7-342-cancer-biology-from-basi...  
主讲教师: Dr. Carla Kim; Dr. Kevin Haigis
开课单位: 麻省理工学院
开课时间: 信息不详。欢迎您在右侧留言补充。
课程语种: 英语
中文简介:
本课程是麻省理工学院生物系开设的许多高级本科课程之一。这些研讨会是为有兴趣利用初级研究文献在高度互动的环境中讨论和学习当前生物研究的学生而设计的。1971年,尼克松总统宣布“向癌症宣战”;但三十年后,战争仍在肆虐。我们在赢得战争方面取得了多少进展?我们在改进战争方面做了什么?了解肿瘤形成、进展和转移过程中所涉及的分子和细胞事件,对于癌症患者创新治疗的发展至关重要。通过对酵母、线虫、小鼠和细胞培养模型的生化、分子和遗传分析的基础研究,对这些过程有了深入的了解。我们将探索用于癌症研究的实验室工具和技术,癌症生物学的重大发现,以及这些突破的医学意义。本课程的重点将是对主要文献的批判性分析,以促进对各种癌症研究方法的优势和局限性的理解。将特别注意在模型生物中进行的癌症研究的临床意义以及结束与这种毁灭性疾病的斗争的前景。
课程简介: This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In 1971, President Nixon declared the "War on Cancer," but after three decades the war is still raging. How much progress have we made toward winning the war and what are we doing to improve the fight? Understanding the molecular and cellular events involved in tumor formation, progression, and metastasis is crucial to the development of innovative therapy for cancer patients. Insights into these processes have been gleaned through basic research using biochemical, molecular, and genetic analysis in yeast, C. elegans, mice, and cell culture models. We will explore the laboratory tools and techniques used to perform cancer research, major discoveries in cancer biology, and the medical implications of these breakthroughs. A focus of the class will be critical analysis of the primary literature to foster understanding of the strengths and limitations of various approaches to cancer research. Special attention will be made to the clinical implications of cancer research performed in model organisms and the prospects for ending the battle with this devastating disease.
关 键 词: 癌症; 肿瘤; 转移; 遗传分析; 肿瘤生物学; 生物模型; 遗传途径; 不受控制的生长; 抑癌基因; 癌基因; 肿瘤发生; 细胞周期; 染色体畸变; 细胞凋亡; 细胞死亡信号转导途径
课程来源: 麻省理工学院公开课
最后编审: 2017-11-26:cmh
阅读次数: 206