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7.343 呼吸的根本后果：活性氧在衰老和疾病中的作用
7.343 The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Disease |
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| 课程网址: |
http://ocw.mit.edu/courses/biology/7-343-the-radical-consequences...
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| 主讲教师: |
Dr. Priyamvada Rai
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| 开课单位: |
麻省理工学院
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| 开课时间: |
信息不详。欢迎您在右侧留言补充。
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| 课程语种: |
英语
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| 中文简介: |
本课程首先介绍基本的氧自由基生化反应，然后讨论细胞和膳食抗氧化剂的作用机制。在考虑了氧化剂的正常生理作用后，我们将研究活性氧升高和细胞氧化还原能力衰竭对机体和细胞衰老速率的影响，以及对几种通常与年龄有关的主要疾病的发病和进展的影响。主题包括罗斯诱导干细胞再生、胰岛素抵抗、心脏病、神经退行性疾病和癌症。还将讨论抗氧化剂在调节活性氧水平的潜在治疗策略中的作用。这门课程是麻省理工学院生物系提供的许多高等本科生研讨会之一。这些研讨会是为有兴趣利用初级研究文献在高度互动的环境中讨论和学习当前生物研究的学生而设计的。许多本科生高级研讨会的讲师都是对教学有浓厚兴趣的博士后科学家。
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| 课程简介: |
This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
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| 关 键 词: |
活性氧; 量; 线粒体; 细胞信号; 抗病原体; 氧化损伤; 癌基因; 抗氧化剂; 胰岛素抵抗; 糖尿病; 干细胞; 神经变性; 缺血; ATP; NADPH; 氮氧化物; PSD; 程序性细胞死亡
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| 课程来源: |
麻省理工学院公开课
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| 最后编审: |
2017-11-26：cmh
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| 阅读次数: |
29
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