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9.15/9.150突触传递的生化和药理学

9.15 / 9.150 Biochemistry and Pharmacology of Synaptic Transmission
课程网址: http://ocw.mit.edu/courses/brain-and-cognitive-sciences/9-15-bioc...  
主讲教师: Prof. Richard Wurtman
开课单位: 麻省理工学院
开课时间: 信息不详。欢迎您在右侧留言补充。
课程语种: 英语
中文简介:
本课程将探讨神经传递的过程,特别是在大脑和其他地方使用的化学物质,将信号从神经末梢传递到它们所支配的结构。我们主要研究单胺类递质(乙酰胆碱;5 -羟色胺;多巴胺和去甲肾上腺素);我们还研究氨基酸和肽传递素以及神经调节素,如腺苷。本文讨论了介导神经递质合成、释放、失活和受体介导行为的大分子,以及调节其活性的因素,以及它们所控制的第二信使系统和离子通量。考虑到人类疾病中某些神经递质的参与。
课程简介: This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. We focus on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); we also examine amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered.
关 键 词: 神经传递素; 抗抑郁; 脑脂质; 脑血管屏障; 多巴胺; 帕金森病; 羟色胺; 谷氨酸; 天门冬,抑郁; 药品; 药物发现; 药物; 信号通路; 受体; 脊髓; 大麻
课程来源: 麻省理工学院公开课
最后编审: 2017-12-03:cmh
阅读次数: 32