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整合分析miRNA和mRNA表达谱，作为识别预后标志物和相关通路的工具

Integrated analysis of miRNA and mRNA expression profiling as a tool to identify prognostic markers and associated pathways
课程网址: http://videolectures.net/cancerbioinformatics2010_buffa_iam/  
主讲教师: Francesca Buffa
开课单位: 牛津大学
开课时间: 2012-05-09
课程语种: 英语
中文简介:
微RNA (miRNA)的表达和功能高度依赖于所考虑的实验系统。在此，我们提出了体内miRNA表达分析的系统观点，这可能有助于识别有效的新治疗方法。具体来说，我们展示了如何将成熟微RNA (miRNA)和miRNA宿主基因(上游)和miRNA靶标(下游)的表达信息结合到临床样本分析中，以发现和评估预后miRNAs及其相关通路，并发现新的miRNA靶标。
课程简介: Micro-RNA (miRNA) expression and function have been shown to be highly dependent upon the experimental system considered. Here we present a systems view of miRNA expression analysis in-vivo that may assist in identification of effective novel therapeutic approaches. Specifically, we show how combined information regarding expression of mature micro-RNAs (miRNA) and of the miRNA host-gene (upstream) and miRNA targets (downstream) can be integrated into analysis of clinical samples, to both discover and assess prognostic miRNAs and their associated pathways, and to discover novel miRNA targets.
关 键 词: 微RNA; 基因的表达与功能; 基因分析; 基因探索工具
课程来源: 视频讲座网
最后编审: 2019-10-22：cwx
阅读次数: 97

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