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自然对生物物流问题的解决方案Nature’s Solution to the Problem of Biological Logistics |
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| 课程网址: | http://videolectures.net/ccss09_maliga_arstbln/ |
| 主讲教师: | Zoltan Maliga |
| 开课单位: | 马克斯普朗克研究所 |
| 开课时间: | 2009-07-10 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | The ability of cells to survive and participate in a community, such as the human body, requires a logistical network that distributes nutrients, cellular contents, and information at biologically reasonable time-scales. How does a robust, adaptable system emerge from the sum of individual hard-wired molecular agents operating in a noisy environment? For example, motor proteins deliver cargo along intracellular filaments to appropriate sites in a network of molecular compartments whose connectivity is slowly becoming elucidated. However, surprisingly little is known about what these motor proteins do, specifically, (1) where they go in cells, (2) what they transport, and (3) how their activity is regulated. To address these basic questions, we modified motor proteins so they could be visualized in live cells and recovered with their physical binding partners. Individual motor proteins were also removed from cells to determine the overall effect on different cellular trafficking pathways. We found that different motor proteins are targeted to unique sub-cellular compartments and identified regulatory proteins resident in these compartments that could serve as molecular postal codes, or otherwise regulate the cycle of cargo binding and release. Overall, this provides an example of a biological solution to managing complex systems using a limited number of components. |
| 关 键 词: | 细胞; 物流网络; 单个硬连线分子; 分子间隔网络; 调节蛋白; 运动蛋白 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-10-22：cwx |
| 阅读次数: | 23 |