图 书 馆
盘基网柄菌聚集过程中螺旋重排成目标模式Rearrangement of Spirals into Target Patterns in the Course of Dictyostelium discoideum Aggregation |
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| 课程网址: | http://videolectures.net/eccs07_polezhaev_rst/ |
| 主讲教师: | Andrey A. Polezhaev |
| 开课单位: | 列贝德夫物理研究所 |
| 开课时间: | 2007-12-14 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | The amoebae Dictyostelium discoideum has been frequently investigated as a suitable model system in the framework of biological pattern formation, signal transduction, cell differentiation and morgenesis (see [1] for a review). Under conditions of starvation populations of these amoebae aggregate due to chemical waves of cAMP. As a cAMP wave passes by a cell, it moves in the opposite direction, consequently towards the origin of the signal, as long as the cAMP-concentration is increasing over time. Formally this system my be regarded as a complex self-organizing network of cells, communicating through chemical medium. The spatio-temporal patterns of cAMP waves are a manifestation of the intrinsic properties of this active medium. Depending on the experimental conditions either spiral or circular-shaped waves of cAMP arise [2]. Sometimes a pattern of one type is transformed into the other one in the course of time. In experiments two different examples for transitions from one to the other type of spatio-temporal patterns were reported [3]. In the first case a continuous transition from the spiral type pattern to target waves was observed at the later stages of aggregation. In the second case the transition was induced by a spatially homogeneous cAMP pulse, when after resetting oscillating spots, bearing target patterns emerged instead of the originally present spirals. Similar results were reported by Lee et al. [4]. The biological significance of different types of cAMP waves for Dictyostelium discoideum morphogenesis and the mechanisms of transitions between them are still unclear. Thus the question arises: what are the internal cellular properties and the external experimental conditions, which lead to such a transition? We attempt to find the answer to this question applying a mathematical modelling approach. |
| 关 键 词: | 变形虫盘基网柄菌; 生物模式; 细胞 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-03-19：lxf |
| 阅读次数: | 64 |