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From Protein-Protein to Domain-Domain Interactions and Back[从蛋白质相互作用到域相互作用和返回}
From Protein-Protein to Domain-Domain Interactions and Back[从蛋白质相互作用到域相互作用和返回} |
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| 课程网址: |
http://videolectures.net/eccs07_schroeder_fpp/
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| 主讲教师: |
Michael Schroeder
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| 开课单位: |
德累斯顿工业大学
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| 开课时间: |
2007-12-14
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| 课程语种: |
英语
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| 中文简介: |
随着源自3D结构和实验确定的大规模蛋白质相互作用网络的域交互网络的出现，出现了许多有趣的问题：交互界面是否比其余表面更保守？蛋白质相互作用网络的结构能否与潜在的域间相互作用相关联？来自域相互作用的基序可以预测蛋白质相互作用吗？病毒结构域可以模仿天然人类蛋白质相互作用界面吗？结构域和蛋白质蛋白质相互作用之间存在复杂的关系，其理解有助于回答上述问题。在演讲中，我将回顾如何构建源自结构域的网络，以及如何通过从文献中提取的相互作用来补充大型实验蛋白质相互作用网络。我将阐述这些网络的结构，如何识别功能模块以及如何预测交互。所讨论的技术将用于鉴定胰腺癌中的候选靶标，并将显示病毒如何干扰其宿主的凋亡程序。
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| 课程简介: |
With the advent of domain interaction networks derived from 3D structures and experimentally determined large-scale protein interaction networks a number of interesting questions arise: Are interaction interfaces more conserved than the rest of the surfaces? Can the structure of protein interaction networks be linked to underlying domain interactions? Can motifs derived from domain interactions predict protein interactions? Can viral domains mimick native human protein interaction interfaces? There is an intricate relationship between domain-domain and protein-protein interactions, whose understanding helps to answer the above questions. In the talk, I will review how to construct networks derived from structural domains and how to complement large-experimental protein interaction networks with interactions extracted from literature. I will shed light onto the structure of these networks, how to identify functional modules, and how to predict interactions. The discussed techniques will be used to identify candidate targets in pancreas cancer and will show how viruses interfere with the apoptotic programme of their hosts.
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| 关 键 词: |
3D结构; 蛋白质; 域交互网络
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| 课程来源: |
视频讲座网
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| 最后编审: |
2019-03-19：lxf
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| 阅读次数: |
92
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