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基于遗传混合和等位基因突变的种群结构推理新型混合模型A New Admixture Model for Inference of Population Structure in Light of Both Genetic Admixing and Allele Mutations |
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| 课程网址: | http://videolectures.net/icml08_shringarpure_nam/ |
| 主讲教师: | Suyash Shringarpure |
| 开课单位: | 卡内基梅隆大学 |
| 开课时间: | 2008-07-29 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Traditional methods for analyzing population structure, such as the Structure program, ignore the influence of mutational effects. We propose mStruct, an admixture of population-specific mixtures of inheritance models, that addresses the task of structure inference and mutation estimation jointly through a hierarchical Bayesian framework, and a variational algorithm for inference. We validated our method on synthetic data, and used it to analyze the HGDP-CEPH cell line panel of microsatellites used in (Rosenberg et al., 2002) and the HGDP SNP data used in (Conrad et al., 2006). A comparison of the structural maps of world populations estimated by mStruct and Structure is presented, and we also report potentially interesting mutation patterns in world populations estimated by mStruct, which is not possible by Structure. |
| 关 键 词: | 种群结构; 贝叶斯框架; 变分算法 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-04-21：lxf |
| 阅读次数: | 83 |