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医院相关C. Diff的患者风险分层作为时间序列分类任务

Patient Risk Stratification for Hospital-Associated C. Diff as a Time-Series Classification Task
课程网址: http://videolectures.net/machine_wiens_patient/  
主讲教师: Jenna Wiens
开课单位: 麻省理工学院
开课时间: 2013-01-18
课程语种: 英语
中文简介:
患者的不良事件风险受时间过程的影响,包括诊断和治疗活动的性质和时间,以及患者病理生理学随时间的整体演变。然而,许多研究者在对患者风险进行建模时忽略了这一时间方面,仅考虑患者的当前或总体状态。我们探索将患者风险表示为时间序列。在这样做时,患者风险分层成为时间序列分类任务。该任务不同于大多数时间序列分析应用,如语音处理,因为必须首先提取时间序列本身。因此,我们首先定义和提取近似\ textit {风险过程},即患者的日常风险。一旦获得,我们使用这些信号来探索时间序列分类的不同方法,目的是识别高风险模式。我们将该分类应用于识别具有\ textit {Clostridium Difficile}的医院获得性定植检测阳性风险的患者的特定任务。我们在数百名患者的持续设定上实现接收器操作特征曲线0.79下的面积。我们对风险分层的两阶段方法优于仅考虑患者当前状态的分类器(p
课程简介: A patient's risk for adverse events is affected by temporal processes including the nature and timing of diagnostic and therapeutic activities, and the overall evolution of the patient's pathophysiology over time. Yet many investigators ignore this temporal aspect when modeling patient risk, considering only the patient's current or aggregate state. We explore representing patient risk as a time series. In doing so, patient risk stratification becomes a time-series classification task. The task differs from most applications of time-series analysis, like speech processing, since the time series itself must first be extracted. Thus, we begin by defining and extracting approximate \textit{risk processes}, the evolving approximate daily risk of a patient. Once obtained, we use these signals to explore different approaches to time-series classification with the goal of identifying high-risk patterns. We apply the classification to the specific task of identifying patients at risk of testing positive for hospital acquired colonization with \textit{Clostridium Difficile}. We achieve an area under the receiver operating characteristic curve of 0.79 on a held-out set of several hundred patients. Our two-stage approach to risk stratification outperforms classifiers that consider only a patient's current state (p
关 键 词: 病理生理学; 患者风险; 时间序列
课程来源: 视频讲座网
最后编审: 2019-05-15:lxf
阅读次数: 89