图 书 馆
性别的演变：对腐烂Y染色体的再思考The Evolution of Sex: Rethinking the Rotting Y Chromosome |
|
| 课程网址: | http://videolectures.net/mitworld_page_chromosome/ |
| 主讲教师: | David C. Page |
| 开课单位: | 怀特黑德生物医学研究所 |
| 开课时间: | 2013-04-19 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | According to David Page, “the Y chromosome is the Rodney Dangerfield of the human genome.” Regarded for 50 years as a genetic wasteland, the Y chromosome just doesn’t get any respect…until now. Page’s lab has made some startling discoveries that reverse the prevailing view. Recall from basic biology that pairs of chromosomes exchange genetic material through a process of crossing over. This leads to genetic variation in offspring, and can weed out dangerous mutations. Although there’s limited gene swapping between the sex-determining X and Y chromosomes, the popular belief has been that a large portion of the Y could not recombine, and therefore will sooner or later self destruct. The long-term outlook for the Y chromosome was bleak. But now there is hope and renewed respect for the Y. Page has found vast sequences of DNA on the Y that appear like palindromes (words like “mom” that read the same backwards and forwards). Page believes the two halves of the palindrome engage in a kind of crossing over. This can lead to repairing mutations, just as in ordinary chromosomes. Through this unique method, the Y chromosome not only endures but prevails. |
| 关 键 词: | Y染色体; 基础生物学; 遗传变异 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-06-11：cjy |
| 阅读次数: | 53 |