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神经生物学:我们如何获取、巩固和回忆记忆

Neurobiology of Memory: How Do We Acquire, Consolidate and Recall Memory
课程网址: http://videolectures.net/mitworld_tonegawa_neme/  
主讲教师: Susumu Tonegawa
开课单位: 麻省理工学院
开课时间: 2010-09-08
课程语种: 英语
中文简介:
在世界各地的实验室中,老鼠学会驾驶复杂的迷宫,找到巧克力奖励,并在一段时间后,以最高效率再次运行迷宫,迅速收集所有的糖果。但在Susumu Tonegawa的实验室中,他创造的突变小鼠无法完成这些任务。 Tonegawa“敲除”一个基因,该基因损害小鼠海马的特定部分,负责空间记忆的大脑区域等等。突变小鼠努力获取并回忆有关其周围环境的信息。 Tonegawa的工作涉及操纵基因以探索记忆,并从最基本的生化和细胞水平学习,直至最复杂的行为。 Tonegawa设计有缺陷的老鼠的目标之一是模拟严重的人类疾病,如精神分裂症。
课程简介: In labs around the world, mice learn to navigate complex mazes, locate chocolaty rewards, and after an interval, run the mazes again with maximum efficiency, swiftly collecting all the sweets. But in Susumu Tonegawa’s lab, the mutant mice he has created cannot perform these tasks. Tonegawa “ knocks out” a gene that impairs a specific part of the mouse hippocampus, the area of the brain responsible for spatial memory, among other things. Mutant mice struggle to acquire and recall information about their surroundings. Tonegawa’s work involves manipulating genes to explore memory and learning from the most basic biochemical and cellular levels, up to the most complex behaviors. One of Tonegawa’s goals in designing defective mice is to simulate profound human disorders, like schizophrenia.
关 键 词: 探索记忆; 基因损害; 精神分裂症
课程来源: 视频讲座网
最后编审: 2020-06-08:cxin
阅读次数: 69