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网络基因和药物：从大规模实验数据中了解基因功能和药物作用模式Networking Genes And Drugs: Understanding Gene Function And Drug Mode Of Action From Large-Scale Experimental Data |
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| 课程网址: | http://videolectures.net/mlsb09_di_bernardo_ngad/ |
| 主讲教师: | Diego di Bernardo |
| 开课单位: | Telethon遗传医学研究所 |
| 开课时间: | 2009-10-05 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | A cell can be described as a synergistic ensemble of biological entities (mRNA, proteins, ncRNA, metabolites, etc) interacting with each other, whose collective behaviour causes the observed phenotypes. A great research effort is ongoing in identifying and mapping the network of interactions among biomolecules in mammalian species. The idea of harnessing this network to understand human diseases at the molecular level, and possibly to find suitable drugs for their treatment, is fascinating but still unfulfilled. We will show how it is possible to harness experimental data on human cells and tissue to identify the gene regulatory networks among tens of thousands of genes, and how to use this information to analyse the modular structure of the cell and predict the function of each gene. Moreover, we will show how using these data it is also possible to identify a suitable drug, or a combination of drugs, that can restore the physiological behaviour of the affected pathways in human diseases. |
| 关 键 词: | 细胞; 生物实体; 人类疾病 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-07-02：cwx |
| 阅读次数: | 70 |