图 书 馆
乳腺癌预后信号的稳定性和可解释性On the stability and interpretability of prognosis signatures in breast cancer |
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| 课程网址: | http://videolectures.net/mlsb2010_haury_ots/ |
| 主讲教师: | Anne-Claire Haury |
| 开课单位: | 居里研究所 |
| 开课时间: | 2010-11-08 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | In this work we wish to answer the questions: (1) how much can we trust the list of genes and the biological functions found in a predictive signature and (2) how do common feature selection methods compare to each other in this regard? We propose a rigorous framework to assess the accuracy, the stability and the interpretability of a feature selection method and compare 8 common feature selection methods as well as ensemble feature selection variants on three breast cancer datasets. Results highlight the very low robustness of most existing methods, including ensemble methods, and raise a warning about the over interpretation of published signatures in terms of genes and biological processes. |
| 关 键 词: | 基因列表; 预测签名; 生物功能 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-07-02：cwx |
| 阅读次数: | 50 |